Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
Oleacein
250
CHF
CHF 250.00
In stock
AG-CN2-0535-M0055 mgCHF 250.00
| Product Details | |
|---|---|
| Synonyms | 3,4-DHPEA-EDA; 3,4-Dihydroxyphenylethanol-elenolic acid dialdehyde; Oleacin |
| Product Type | Chemical |
| Properties | |
| Formula |
C17H20O6 |
| MW | 320.3 |
| CAS | 149183-75-5 |
| Source/Host Chemicals | Isolated from Olea europaea. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Yellow to amber oil. |
| Solubility | Soluble in DMSO, dichloromethane or acetonitrile. Slightly soluble in methanol, ethanol or water (0.1mg/ml). |
| Identity | Determined by 1H-NMR. |
| Other Product Data |
Note: Shown to react spontaneously with water or methanol to give mixtures of hemiacetals or acetals (see Karkoula et al 2012). |
| InChi Key | XLPXUPOZUYGVPD-VMPILDALSA-N |
| Smiles | OC1=C(O)C=CC(CCOC(C[C@H](CC([H])=O)/C(C([H])=O)=C\C)=O)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Oleacin is a phenolic compound of extra virgin olive oil and has antioxidant, anti-inflammatory, antitumor, antiproliferative, antimicrobial, cardioprotective, antiobesity and antiatherosclerotic properties.
- In vitro studies showed that oleacein reduces ROS production by f-MLP and PMA-stimulated neutrophils (inhibiting the release of myeloperoxidase).
- 5-Lipoxygenase (5-LOX) and NF-κB signaling inhibitor.
- Improves insulin sensitivity in obese mice.
- Dual substrate-inhibitor of catechol-O-methyltransferase. Inhibits the catalytic activities of nicotinamide N-methyltransferase, ATP-citrate lyase, lysine-specific demethylase 6A and N-methyltransferase 4.
Product References
- Simple and hydrolyzable compounds in virgin olive oil. 3. Spectroscopic characterizations of the secoiridoid derivatives: G. Montedoro, et al.; J. Agric. Food Chem. 41, 2228 (1993)
- Isolation of an angiotensin converting enzyme (ACE) inhibitor from Olea europaea and Olea lancea: K. Hansen, et al.; Phytomedicine 2, 319 (1996)
- Comparison of the concentrations of phenolic compounds in olive oils and other plant oils: Correlation with antimicrobial activity: E. Medina, et al.; J. Agr. Food Chem. 54, 4954 (2006)
- Direct Measurement of Oleocanthal and Oleacein Levels in Olive Oil by Quantitative 1H NMR. Establishment of a New Index for the Characterization of Extra Virgin Olive Oils: E. Karkoula, et al.; J. Agric. Food Chem. 60, 11696 (2012)
- Inhibition of human neutrophils NEP activity, CD11b/CD18 expression and elastase release by 3,4-dihydroxy-phenylethanol-elenolic acid dialdehyde, oleacein: M.E. Czerwinska, et al.; Food Chem. 153, 1 (2014)
- One-step semisynthesis of oleacein and the determination as a 5-lipoxygenase inhibitor: K. Vougogiannopoulou, et al.; J. Nat. Prod. 77, 441 (2014)
- Oleacein. translation from Mediterranean diet to potential antiatherosclerotic drug: M. Naruszewicz, et al.; Curr. Pharm. Des. 21, 1205 (2015) (Review)
- Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice: G.E. Lombardo, et al.; Front. Endocrinol. 9, 116 (2018)
- The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase: E. Cuyas, et al.; Food Chem. Toxicol. 128, 35 (2019)
- Computational de-orphanization of the olive oil biophenol oleacein: Discovery of new metabolic and epigenetic targets: E. Cuyas, et al.; Food Chem. Toxicol. 131, 110529 (2019)
- Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma: G. Juli, et al.; Cancers 11, E990 (2019)
- Oleacein Prevents High Fat Diet-Induced Adiposity and Ameliorates Some Biochemical Parameters of Insulin Sensitivity in Mice: S.M. Lepore, et al.; Nutrients 11, E1829 (2019)
- The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-kappaB Activation: S. Carpi, et al.; Nutrients 11, E2855 (2019)
- Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health: A. Karkovic Markovic, et al.; Molecules 24, E2001 (2019)
- Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells: S. Cirmi, et al. Food Function 11, 3271 (2020)
Related Products
