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Oleuropein

CHF 55.00
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AG-CN2-0538-M02525 mgCHF 55.00
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Product Details
Synonyms Oleoeuropein
Product Type Chemical
Properties
Formula

C25H32O13

MW 540.5
CAS 32619-42-4
Source/Host Chemicals Isolated from Olea europaea.
Purity Chemicals ≥98% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in DMSO (30mg/ml), ethanol (30mg/ml) or dimethylformamide (50mg/ml).
Identity Determined by 1H-NMR.
InChi Key RFWGABANNQMHMZ-ZCHJGGQASA-N
Smiles OC1=C(O)C=CC(CCOC(C[C@H]2/C([C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)OC=C2C(OC)=O)=C\C)=O)=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Oleuropein is a polyphenol from olive leaves and fruits that hydrolyzes to form hydroxytyrosol and tyrosol.
  • Oleuropein exhibits antioxidant, anti-inflammatory, anticancer, antimicrobial, antifungal, antiviral, antiobesity, antidiabetic, antihypertensive, hypolipidemic, hepatoprotective and neuroprotective properties.
  • Free radical-scavenging compound.
  • Inhibits cell proliferation, cell growth, migration, invasion and angiogenesis and induces apoptosis and cell cycle arrest in cancer cells but not normal cells. Modulates gene expression and activity of a variety of different signaling proteins that play a role in proliferation and apoptosis. Induces autophagy by activating AMPK.
  • Potential agent against metabolic syndrome. Reduces adipogenesis by antagonizing PPARγ. Enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating β-adrenergic signaling. Promotes β cell insulin secretion and protects β cells from amylin amyloid-induced cytotoxicity. Improves insulin resistance by promoting GLUT4 translocation.
  • Inhibits expression of inflammatory mediators by suppressing the activation of NF-κB and MAPKs.
  • HIV-1 fusion and integrase inhibitor.
Product References
  1. Studies on the mechanism of the antimicrobial action of oleuropein: B. Juven, et al.; J. Appl. Bacteriol. 35, 559 (1972)
  2. Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein: I. Kruk, et al.; Luminescence 20, 81 (2005)
  3. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor: H.K. Hamdi & R. Castellon; BBRC 334, 769 (2005)
  4. Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. fusion [corrected] inhibition: S. Lee-Huang, et al.; BBRC 354, 872 (2007)
  5. Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: part II. integrase inhibition: S. Lee-Huang, et al.; BBRC 354, 879 (2007)
  6. Oleuropein in olive and its pharmacological effects: S.H. Omar; Sci. Pharm. 78, 133 (2010) (Review)
  7. Oleuropein, an anti-oxidant polyphenol constituent of olive promotes α-secretase cleavage of the amyloid precursor protein (AβPP): M. Kostomoiri, et al.; Cell Mol. Neurobiol. 33, 147 (2013)
  8. Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma: M. Svobodova, et al.; Genes Nutr. 9, 376 (2014)
  9. Antifungal Activity of Oleuropein against Candida albicans-The In Vitro Study: N. Zoric, et al.; Molecules 21, E1631 (2016)
  10. Anticancer effects of oleuropein: H. Shamshoum, et al.; Biofactors 43, 517 (2017) (Review)
  11. Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating β-adrenergic signaling: Y. Oi-Kano, et al.; J. Nutr. Biochem. 40, 209 (2017)
  12. Olive Component Oleuropein Promotes β-Cell Insulin Secretion and Protects β-Cells from Amylin Amyloid-Induced Cytotoxicity: L. Wu, et al.; Biochemistry 56, 5035 (2017)
  13. Oleuropein inhibits the IL-1β-induced expression of inflammatory mediators by suppressing the activation of NF-κB and MAPKs in human osteoarthritis chondrocytes: Z. Feng, et al.; Food Funct. 8, 3737 (2017)
  14. Oleuropein improves insulin resistance in skeletal muscle by promoting the translocation of GLUT4: Y. Fujiwara, et al.; J. Clin. Biochem. Nutr. 61, 196 (2017)
  15. Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates: M. Imran, et al.; J. Food Sci. 83, 1781 (2018) (Review)
  16. Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome: J. Ahamad, et al.; Phytother. Res. 33, 3112 (2019) (Review)
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