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Chemodex
Hydroxytyrosol
81
CHF
CHF 81.00
In stock
CDX-H0155-M02525 mgCHF 81.00
CDX-H0155-M100100 mgCHF 204.00
| Product Details | |
|---|---|
| Synonyms | 3-Hydroxytyrosol; 2-(3,4-Dihydroxyphenyl)ethanol; 3,4-Dihydroxyphenethyl alcohol; DOPET; 3,4-DHPEA; Ba2774 |
| Product Type | Chemical |
| Properties | |
| Formula |
C8H10O3 |
| MW | 154.16 |
| CAS | 10597-60-1 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow liquid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | JUUBCHWRXWPFFH-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(CCO)C=C1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Phenolic component of olive oil. Metabolite of oleuropein. Antioxidant that inhibits both 12- and 5-lipoxygenase (LO) activity. The IC50 values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13µM, respectively. It does not inhibit, and may actually enhance, COX activity. Protects LDL from both biological and chemical oxidation, suggesting a potential mechanism for the protective effects of olive oil against atherosclerosis. Inhibits the rate of cancer cell proliferation and induces cancer cell apoptosis. Also described to induce growth arrest and apoptosis in human colon carcinoma HT-29 cells through activation of the serine/threonine protein phosphatase 2A. Protects β-Cells from amylin amyloid-Induced cytotoxicity.
Product References
(1) N. Kohyama, et al.; Biosci. Biotechnol. Biochem. 61, 347 (1997) | (2) P. Grignaffini, et al.; Lancet 343, 1296 (1994) | (3) C. Manna, et al.; J. Nutr. 127, 286 (1997) | (4) C.A. Palmerini, et al.; J. Nutr. Biochem. 16, 109 (2005) | (5) C. Guichard, et al.; Carcinogenesis 27, 1812 (2006) | (6) L. Wu, et al.; Biochemistry 56, 5035 (2017)
Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health: A. Karkovic Markovic, et al.; Molecules 24, E2001 (2019)
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