AdipoGen Life Sciences

Ganglioside GD1b . disodium salt

CHF 210.00

In stock

AG-CN2-9004-M0011 mgCHF 210.00

More Information
Product Details
Synonyms	GD1b . 2Na; Disialoganglioside GD1b . 2Na
Product Type	Chemical
Properties
Formula	C₈₄H₁₄₆N₄O₃₉ . 2Na
MW	1836.1 . 46.0 (calculated on sphingosine C18:1 and stearic acid)
Sequence	Structure: II³Neu5Ac₂GgOse₄Cer; β-Gal-(1-3)-β-GalNAc-(1-4)-[α-Neu5Ac-(2-8)-α-Neu5Ac -(2-3)-]β-Gal-(1-4)-β-Glc-(1-1)-Cer; Cer: Sphingosine C18:1-C20:1, ~1:1 to 1:3 by vol.; stearic acid over 90%
CAS	19553-76-5
Source/Host Chemicals	Isolated from bovine brain.
Purity Chemicals	≥98% (TLC)
Solubility	Soluble in water (micellar aggregates) or chloroform:methanol (2:1).
Formulation	Lyophilized.
Endotoxin Content	Not detectable.
Identity	Determined by 1H-NMR, MS and HPTLC.
InChi Key	ACTJLGSQQMVYGN-SWRXABKPSA-L
Smiles	[Na+].[Na+].[H][C@@](O)(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@@]([H])(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@@H]1C(O)[C@H](O[C@H]2C(O)C(O)[C@H](OC[C@]([H])(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)\C=C\CCCCCCCCCCCCC)O[C@H]2CO)OC(CO)[C@@H]1O[C@H]1O[C@@H](CO)[C@H](O)C(O[C@@H]2OC(CO)[C@@H](O)[C@H](O)C2O)C1NC(C)=O)C([O-])=O)C([O-])=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Hygroscopic. Protect from moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD1b may act as a bacterial toxin receptor (tetanus, botulinus). High levels are found in gliomas and astrocytomas. It modulates protein kinase activities. In vivo and in vitro it is in equilibrium with the lactone structure.

Product References

Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)
Natural occurrence of ganglioside lactones. Isolation and characterization of GD1b inner ester from adult human brain: L. Riboni, et al.; J. Biol. Chem. 261, 8514 (1986)
Exogenous gangliosides GD1b and GD1b-lactone, stably associated to rat brain P2 subcellular fraction, modulate differently the process of protein phosphorylation: R. Bassi, et al.; J. Neurochem. 57, 1207 (1991)
Immunohistochemical staining for ganglioside GD1b as a diagnostic and prognostic marker for primary human brain tumors: T.C. Comas, et al.; Neuro Oncol. 1, 261 (1999)
Dynamic and structural properties of sphingolipids as driving force to the formation of membrane domains: S. Sonnino, et al.; Chem. Rev. 106, 2111 (2006)

Call	+41 61 926 6040
Fax	+41 61 926 6049