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AdipoGen Life Sciences
Asialo-Ganglioside GM2
300
CHF
CHF 300.00
In stock
AG-CN2-9009-C100100 µgCHF 300.00
| Product Details | |
|---|---|
| Synonyms | Ceramide trihexoside; Gangliotriosylceramide; Asialoganglioside-GM2; ASGM2 |
| Product Type | Chemical |
| Properties | |
| Formula |
C56H104N2O18 |
| MW |
1093.4 (calculated on sphingosine C18:1 and stearic acid) |
| Sequence |
Structure: GgOse3Cer; β-GalNAc-(1-4)-]β-Gal-(1-4)-β-Glc-(1-1)-Cer; Cer: Sphingosine C18:1-C20:1, ~1:1 by vol.; stearic acid over 90% |
| CAS | 35960-33-9 |
| Source/Host Chemicals | Semisynthetic. |
| Purity Chemicals | ≥98% (TLC) |
| Solubility | Soluble in chloroform:methanol (2:1). |
| Formulation | Lyophilized. |
| Endotoxin Content | Not detectable. |
| Identity | Determined by 1H-NMR, MS and HPTLC. |
| InChi Key | FOCMISOLVPZNSV-ZLIWCFRDSA-N |
| Smiles | [H][C@@](CO[C@@H]1O[C@@H](CO)[C@@H](O[C@@H]2OC(CO)[C@H](O[C@H]3O[C@@H](CO)[C@H](O)C(O)C3NC(C)=O)[C@H](O)C2O)C(O)C1O)(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)\C=C\CCCCCCCCCCCCC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Asialo-ganglioside GM2 is a major neural ganglioside in Tay Sachs and Sandhoff diseases.
Product References
Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)
Establishment of anti-asialo-GM1 rabbit monoclonal antibodies capable of reducing natural killer cell activity in mice PLoS One 18, e0292514 (2023)
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