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AdipoGen Life Sciences
Ganglioside GD3 . disodium salt
235
CHF
CHF 235.00
In stock
AG-CN2-9005-C500500 µgCHF 235.00
AG-CN2-9005-M0011 mgCHF 385.00
| Product Details | |
|---|---|
| Synonyms | GD3 . 2Na; Disialoganglioside GD3 . 2Na |
| Product Type | Chemical |
| Properties | |
| Formula |
C70H123N3O29 . 2Na |
| MW |
1470.8 . 46.0 (calculated on sphingosine C18:1 and stearic acid) |
| Sequence |
Structure: α-Neu5Ac-(2-8)-α-Neu5Ac-(2-3)-β-Gal-(1-4)-β-Glc-(1-1)-Cer; Cer: Sphingosine C18:1-C20:1, ~1:1 to 1:3 by vol.; stearic acid over 90% |
| CAS | 62010-37-1 |
| Source/Host Chemicals | Isolated from bovine brain. |
| Purity Chemicals | ≥98% (TLC) |
| Solubility | Soluble in water or chloroform:methanol (2:1). |
| Formulation | Lyophilized. |
| Endotoxin Content | Not detectable. |
| Identity | Determined by 1H-NMR, MS and HTPLC. |
| InChi Key | LGRBZCLULGFXOD-MIJDSYIJSA-L |
| Smiles | [Na+].[Na+].[H][C@@](O)(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@@]([H])(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@H]1[C@H](O)C(CO)O[C@@H](O[C@H]2C(O)C(O)[C@H](OC[C@]([H])(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)\C=C\CCCCCCCCCCCCC)O[C@H]2CO)C1O)C([O-])=O)C([O-])=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD3 induces mitochondrial permeability transition (MPT) without requiring elevated Ca2+ levels and thus triggers Fas-mediated apoptosis. It modulates the activity of Src-family tyrosine kinase Lyn and cell apoptosis. It is involved in several tumor processes and is high abundant in proliferating cells and in the first stage of neuronal differentiation.
Product References
- Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)
- Gangliosides and neuronal differentiation: H. Rosner, et al.; Neurochem. Int. 20, 339 (1992)
- Ganglioside GD3 as a raft component in cell death regulation: M. Sorice, et al.; Anticancer Agents Med. Chem. 12, 376 (2012)
- Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones: N. Sekino-Suzuki, et al.; J. Neurochem. 124, 514 (2013)
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