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AdipoGen Life Sciences
CTPB
60
CHF
CHF 60.00
In stock
AG-CR1-0141-M0011 mgCHF 60.00
AG-CR1-0141-M0055 mgCHF 180.00
| Product Details | |
|---|---|
| Synonyms | N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C31H43ClF3NO2 |
| MW | 554.1 |
| CAS | 586976-24-1 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white crystalline solid. |
| Solubility | Soluble in DMSO and other organic solvents. |
| Identity | Determined by 1H-NMR. |
| InChi Key | OYBMVMAXKOGYDC-UHFFFAOYSA-N |
| Smiles | CCCCCCCCCCCCCCCC1=C(C(=O)NC2=CC(=C(Cl)C=C2)C(F)(F)F)C(OCC)=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent activator of p300 HAT (histone acetyltransferase) activity, which has an important role in regulation of gene expression.
- Does not show PCAF (p300/CBP-associated factor) HAT activities.
- Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.
Product References
- Small molecule modulators of histone acetyltransferase p300: K. Balasubramanyam, et al.; J. Biol. Chem. 278, 19134 (2003)
- Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy: K. Mantelingu, et al.; J. Phys. Chem. B. 111, 4527 (2007)
- Synthesis of benzamides related to anacardic acid and their histone acetyltransferase (HAT) inhibitory activities: J.A. Souto, et al.; ChemMedChem 3, 1435 (2008)
- Intrinsically fluorescent carbon nanospheres as a nuclear targeting vector: delivery of membrane-impermeable molecule to modulate gene expression in vivo: B.R. Selvi, et al.; Nano Lett. 8, 3182 (2008)
- Exploring the binding affinities of p300 enzyme activators CTPB and CTB using docking method: B. Devipriya, et al.; Indian J. Biochem. Biophys. 47, 364 (2010)
- Charge density distribution and the electrostatic moments of CTPB in the active site of p300 enzyme: a DFT and charge density study: B. Devipriya & P. Kumaradhas; J. Theor. Biol. 335, 119 (2013)
- Histone hypoacetylation contributes to neurotoxicity induced by chronic nickel exposure in vivo and in vitro: C. Zhou, et al.; Sci. Total Environ. 783, 147014 (2021)
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