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AdipoGen Life Sciences
AdipoRon . hydrochloride (water soluble)
90
CHF
CHF 90.00
In stock
AG-CR1-0156-M01010 mgCHF 90.00
AG-CR1-0156-M05050 mgCHF 360.00
| Product Details | |
|---|---|
| Synonyms | 2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H28N2O3 . HCl . H2O |
| MW | 428.5 . 36.5 . 18.0 |
| CAS | 924416-43-3 (free base) |
| Purity Chemicals | ≥98% (HPLC, NMR) |
| Appearance | White solid. |
| Solubility | Highly soluble in DMSO (~50mg/ml). Soluble in 100% ethanol or methanol. Slightly soluble in water (1mg/ml). |
| Identity | Determined by 1H-NMR. |
| InChi Key | TZVJQEGKRLDTHQ-UHFFFAOYSA-N |
| Smiles | [Cl-].O=C(COC1=CC=C(C=C1)C(=O)C1=CC=CC=C1)NC1CC[NH+](CC2=CC=CC=C2)CC1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low μm concentration [1, 2].
- Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells [1].
- Activates peroxisome proliferator-activated receptor γ coactivator 1-α (PGC1α) which boosts mitochondrial proliferation and energy metabolism [1].
- Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms [1].
- Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet [1].
- Reduces expression levels of genes encoding inflammatory cytokines such as TNF-α, IL-6 and CCL-2 in WAT of WT mice but not db/db mice [1].
Product References
- A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity: M. Okada-Iwabu, et al.; Nature 503, 493 (2013)
- Cell Biology. Ronning after the adiponectin receptors: W.L. Holland & P.E. Scherer; Science 342, 1460 (2013)
- Activation of adiponectin receptors has negative impact on muscle mass in C2C12 myotubes and fast-type mouse skeletal muscle: R. Ito, et al.; PLoS ONE 13, e0205645 (2018)
- Infuence of adiponectin and infammatory cytokines in fatty degenerative atrophic muscle: I. Shinohara, et al.; Nature Sci. Rep. 12, 1557 (2022)
- Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice: P. Balasubramanian, et al.; eLife 11, e71282 (2022)
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