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AdipoGen Life Sciences
Compound 112254 . hydrochloride (water soluble)
120
CHF
CHF 120.00
In stock
AG-CR1-0157-M01010 mgCHF 120.00
AG-CR1-0157-M05050 mgCHF 480.00
| Product Details | |
|---|---|
| Synonyms | 4-(tert-Butyl)-N-(3-(4-(4-methoxybenzyl)piperazin-1-yl)-3-oxopropyl)benzamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C26H35N3O3 . HCl . H2O |
| MW | 437.6 . 36.5 . 18.0 |
| CAS | 949745-75-9 (free base) |
| Purity Chemicals | ≥98% (HPLC, NMR) |
| Appearance | White crystalline solid. |
| Solubility | Highly soluble in DMSO. Soluble in 100% ethanol or methanol. Slightly soluble in water (1mg/ml). |
| Identity | Determined by 1H-NMR. |
| InChi Key | VLVXNJKVPFIWMW-UHFFFAOYSA-N |
| Smiles | [Cl-].COC1=CC=C(C[NH+]2CCN(CC2)C(=O)CCNC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 less potent than AdipoRon (Prod. No. AG-CR1-0154) [1, 2].
- Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells [1].
- Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms [1].
Product References
- A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity: M. Okada-Iwabu, et al.; Nature 503, 493 (2013)
- Cell Biology. Ronning after the adiponectin receptors: W.L. Holland & P.E. Scherer; Science 342, 1460 (2013)
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