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AdipoGen Life Sciences
GYY 4137
65
CHF
CHF 65.00
In stock
AG-CR1-3513-M01010 mgCHF 65.00
AG-CR1-3513-M05050 mgCHF 260.00
| Product Details | |
|---|---|
| Synonyms | 4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt |
| Product Type | Chemical |
| Properties | |
| Formula |
C11H16NO2PS2 . C4H9NO |
| MW | 288.4 . 87.1 |
| CAS | 106740-09-4 |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO or water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | YZMHNNLDUWRZFW-UHFFFAOYSA-N |
| Smiles | C1COCC[NH2+]1.COC1=CC=C(C=C1)P([S-])(=S)N1CCOCC1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Water-soluble, slow-releasing hydrogen sulfide (H2S) donor [1].
- Exhibits vasodilator and antihypertensive activity [1, 2, 4].
- Anti-inflammatory [2, 3].
- Inhibits LPS-induced release of proinflammatory mediators (IL-1β, IL-6, TNF-α, nitric oxide (NO) and PGE2) and increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-κB, ATF-2 and HSP27 dependent pathways [2, 3].
- Causes stomatal opening and reduces nitric oxide accumulation in plants [5].
- Oxidative stress-induced cell death inhibitor [6].
- Shows novel anti-cancer effects in vitro and in vivo [7].
- Anti-thrombotic via p-selectin dependent mechanism [8].
Product References
- Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.: L. Li et, al.; Circulation 117, 2351 (2008)
- GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.: L. Li, et al.; Free Radic. Biol. Med. 47, 103 (2009)
- The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages: M. Whiteman, et al.; Antioxid. Redox Signal. 12, 1147 (2010)
- Hydrogen sulfide and its modulation in arterial hypertension and atherosclerosis: J. Bełtowski, et al.; Cardiovasc. Hematol. Agents Med. Chem. 8, 173 (2010)
- A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation: M. Lisjak, et al.; Plant Physiol. Biochem. 48, 931 (2010)
- Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is h(2) S a novel cytoprotective mediator in the inflamed joint?: B. Fox, et al.; J. Cell. Mol. Med. 16, 896 (2012)
- The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo: Z.W. Lee, et al.; PLOS One 6, e21077 (2011)
- The slow releasing H2S donor GYY 4137 exerts anti-thrombotic effects via a P-selectin dependent mechanism: E. Grambow, et al.; DGCH München (Meeting Abstract) (2011)
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