AdipoGen Life Sciences

IHR-1

As low as CHF 45.00

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AG-CR1-3526-M0011 mgCHF 45.00

AG-CR1-3526-M0055 mgCHF 110.00

Specifications / Handling

More Information
Product Details
Synonyms	Inhibitor of Hedgehog Response 1; N,N'-1,4-Phenylene bis[2,5-dichloro-benzamide
Product Type	Chemical
Properties
Formula	C₂₀H₁₂Cl₄N₂O₂
MW	454.1
CAS	548779-60-8
Purity Chemicals	≥98% (NMR)
Appearance	White to grey solid.
Solubility	Soluble in DMSO.
Identity	Determined by ¹H-NMR and HR-MS.
InChi Key	VCLHHRGZKNUOAQ-UHFFFAOYSA-N
Smiles	ClC1=CC(C(=O)NC2=CC=C(NC(=O)C3=CC(Cl)=CC=C3Cl)C=C2)=C(Cl)C=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound.
Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only.
Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.

Product-specific References

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation: C.W. Fan, et al.; Chem. Biol. 21, 1680 (2014)

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