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AdipoGen Life Sciences
IHR-1
45
CHF
CHF 45.00
In stock
AG-CR1-3526-M0011 mgCHF 45.00
AG-CR1-3526-M0055 mgCHF 110.00
| Product Details | |
|---|---|
| Synonyms | Inhibitor of Hedgehog Response 1; N,N'-1,4-Phenylene bis[2,5-dichloro-benzamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H12Cl4N2O2 |
| MW | 454.1 |
| CAS | 548779-60-8 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to grey solid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR and HR-MS. |
| InChi Key | VCLHHRGZKNUOAQ-UHFFFAOYSA-N |
| Smiles | ClC1=CC(C(=O)NC2=CC=C(NC(=O)C3=CC(Cl)=CC=C3Cl)C=C2)=C(Cl)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound.
- Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only.
- Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.
Product References
- The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation: C.W. Fan, et al.; Chem. Biol. 21, 1680 (2014)
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