AdipoGen Life Sciences


CHF 45.00
In stock
AG-CR1-3526-M0011 mgCHF 45.00
AG-CR1-3526-M0055 mgCHF 110.00
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Product Details
Synonyms Inhibitor of Hedgehog Response 1; N,N'-1,4-Phenylene bis[2,5-dichloro-benzamide
Product Type Chemical


MW 454.1
CAS 548779-60-8
Purity Chemicals ≥98% (NMR)
Appearance White to grey solid.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR and HR-MS.
Smiles ClC1=CC(C(=O)NC2=CC=C(NC(=O)C3=CC(Cl)=CC=C3Cl)C=C2)=C(Cl)C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound.
  • Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only.
  • Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.
Product References
  1. The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation: C.W. Fan, et al.; Chem. Biol. 21, 1680 (2014)
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