AdipoGen Life Sciences

VR23 [Proteasome Inhibitor]

CHF 35.00

In stock

AG-CR1-3676-M0011 mgCHF 35.00

AG-CR1-3676-M0055 mgCHF 140.00

AG-CR1-3676-M02525 mgCHF 420.00

More Information
Product Details
Synonyms	7-Chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]quinoline
Product Type	Chemical
Properties
Formula	C₁₉H₁₆ClN₅O₆S
MW	477.9
CAS	1624602-30-7
Purity Chemicals	≥98% (HPLC)
Appearance	White solid.
Solubility	Soluble in DMSO (10mg/ml) or DMF. Poorly soluble in aqueous solutions.
Identity	Determined by ¹H-NMR.
Other Product Data	Note: Warming and sonication may be required when dissolving the compound in the solvent of choice. Stock solutions are stable for at least 1 month when stored at -20°C.
InChi Key	PDQVZPPIHADUOO-UHFFFAOYSA-N
Smiles	O=S(N1CCN(C2=C(C=CC(Cl)=C3)C3=NC=C2)CC1)(C4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O)=O
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Potent selective and reversible chloroquine derivative 20S proteasome inhibitor (all proteolytic subunits).
Targets the trypsin-like β2 subunit of the constitutive 20S proteasome (IC₅₀=1nM). Cross-reacts and inhibits the chymotrypsin-like β5 subunit (IC₅₀=50-100nM) and the caspase-like/peptidyl-glutamyl peptide-hydrolyzing (PGPH) β1 subunit (IC₅₀=3μM).
Anticancer compound effective in cell-based assays and against multiple myeloma and metastatic breast cancer in vivo.
In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, as well as in bortezomib-resistent multiple myeloma cells, but with minimal effects on non-cancerous cells.

Product References

VR23: A Quinoline-Sulfonyl Hybrid Proteasome Inhibitor That Selectively Kills Cancer via Cyclin E-Mediated Centrosome Amplification: S. Pundir, et al.; Cancer Res. 75, 4164 (2015)

Call	+41 61 926 6040
Fax	+41 61 926 6049