anti-CD275 (human), mAb antibody (ANC4E3) (Biotin)

Specifications / Handling

More Information
Product Details
Synonyms	B7-H2; ICOS Ligand; B7-like Protein Gl50; B7RP-1
Product Type	Monoclonal Antibody
Properties
Clone	ANC4E3
Isotype	Mouse IgG1κ
Immunogen/Antigen	Human Raji cells, recombinant human CD275-muIg.
Label/Conjugates	Biotin
Application	ELISA
Crossreactivity	Human
Formulation	50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative).
Isotype Negative Control	Mouse IgG1 Isotype Control (Biotin)
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by Ancell Corporation.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

The inducible costimulator CD278 (ICOS) is similar to human CD28 (24% homology) and plays an analogous role in the T cell activation process. Signaling through CD278 is particularly important in progression of TH2 immune response. The receptor for human CD278 (ICOS) is CD275 (GL50), a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2). Blockade of the CD278-CD275 interaction in mice improves allograft survival and reduces EAE.

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anti-CD275 [B7-H2] (human), mAb (ANC4E3) (Biotin)