anti-CD274 [B7-H1/PD-L1] (human), mAb (ANC6H1) (Biotin)

CHF 423.00
In stock
ANC-274-030100 µgCHF 423.00
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Product Details
Synonyms B7-H1; Programmed Cell Death 1 Ligand 1; PD-L1; PDCD1 Ligand 1
Product Type Monoclonal Antibody
Clone ANC6H1
Isotype Mouse IgG1κ
Immunogen/Antigen Recombinant human CD274(B7-H1).
Label/Conjugates Biotin

Flow Cytometry

Crossreactivity Human
Formulation 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative).
Isotype Negative Control

Mouse IgG1 Isotype Control (Biotin)

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by Ancell Corporation.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
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Product Specification Sheet
Datasheet Download PDF

CD274 (B7-H1; PD-L1; Programmed Death Ligand) is a member of the B7 family and is expressed on a variety of tissues including lymphoid cells. It plays an important role in regulation of T cell activation and is involved in progression of cancer, arthritis and HIV infection. CD274 binding to its receptor CD279 (PD-1) on activated T cells can decrease proliferation. Conversely, ligation of CD279 on primed T cells can stimulate IL-10 production. High levels of CD274 present in renal cell carcinoma is associated with poor prognosis. Tumor expressed CD274 can increase apoptosis of tumor specific T cells resulting in better tumor cell survival.

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