Ancell

anti-CD274 [B7-H1/PD-L1] (human), mAb (ANC6H1) (FITC)

CHF 423.00

In stock

ANC-274-040120 testsCHF 423.00

More Information
Product Details
Synonyms	B7-H1; Programmed Cell Death 1 Ligand 1; PD-L1; PDCD1 Ligand 1
Product Type	Monoclonal Antibody
Properties
Clone	ANC6H1
Isotype	Mouse IgG1κ
Immunogen/Antigen	Recombinant human CD274(B7-H1).
Label/Conjugates	FITC
Application	Flow Cytometry ELISA
Crossreactivity	Human
Formulation	50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative).
Isotype Negative Control	Mouse IgG1 Isotype Control (FITC)
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by Ancell Corporation.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Avoid freeze/thaw cycles. Do not freeze. Protect from light.
Use/Stability	Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

CD274 (B7-H1; PD-L1; Programmed Death Ligand) is a member of the B7 family and is expressed on a variety of tissues including lymphoid cells. It plays an important role in regulation of T cell activation and is involved in progression of cancer, arthritis and HIV infection. CD274 binding to its receptor CD279 (PD-1) on activated T cells can decrease proliferation. Conversely, ligation of CD279 on primed T cells can stimulate IL-10 production. High levels of CD274 present in renal cell carcinoma is associated with poor prognosis. Tumor expressed CD274 can increase apoptosis of tumor specific T cells resulting in better tumor cell survival.

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