anti-CD274 [B7-H1/PD-L1] (human), mAb (ANC6H1) (R-PE)

CHF 384.00
In stock
ANC-274-050120 testsCHF 384.00
More Information
Product Details
Synonyms B7-H1; Programmed Cell Death 1 Ligand 1; PD-L1; PDCD1 Ligand 1
Product Type Monoclonal Antibody
Properties
Clone ANC6H1
Isotype Mouse IgG1κ
Immunogen/Antigen Recombinant human CD274(B7-H1).
Label/Conjugates R-PE
Application

Flow Cytometry
ELISA

Crossreactivity Human
Formulation 50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative).
Isotype Negative Control

Mouse IgG1 Isotype Control (R-PE)

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by Ancell Corporation.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Do not freeze.
Protect from light.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

CD274 (B7-H1; PD-L1; Programmed Death Ligand) is a member of the B7 family and is expressed on a variety of tissues including lymphoid cells. It plays an important role in regulation of T cell activation and is involved in progression of cancer, arthritis and HIV infection. CD274 binding to its receptor CD279 (PD-1) on activated T cells can decrease proliferation. Conversely, ligation of CD279 on primed T cells can stimulate IL-10 production. High levels of CD274 present in renal cell carcinoma is associated with poor prognosis. Tumor expressed CD274 can increase apoptosis of tumor specific T cells resulting in better tumor cell survival.

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