OAS1 (human) (rec.) (His) (Active) (10µg)

Specifications / Handling

More Information
Product Details
Synonyms	2'-5' Oligoadenylate Synthetase 1
Product Type	Protein
Properties
Source/Host	E. coli
Sequence	Full-length human 2'-5' oligoadenylate synthetase 1 (OAS1) fused to a His-tag.
Crossreactivity	Human
Application	For use with Transcreener 2-5A OAS activity assays.
Biological Activity	For the specific activity please refer to the Certificate of Analysis for each individual enzyme lot.
MW	43.9kDa
Purity	≥95% (SDS-PAGE)
Accession Number	P00973
Formulation	Liquid. In 20mM Tris-HCl, pH 8.0, 10% glycerol, 1 mM DTT buffer composition.
Other Product Data	Uniprot P00973: OAS1 (human)
Shipping and Handling
Shipping	DRY ICE
Short Term Storage	-20°C
Long Term Storage	-80°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -80°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

The OAS proteins and cGAS are template-independent nucleotidyltransferases that, once activated by double-stranded nucleic acids in the cytosol, produce unique classes of 2'-5'-linked second messenger molecules, which through distinct mechanisms have crucial antiviral functions. 2'-5'-linked oligoadenylates limit viral propagation through the activation of the enzyme RNase L, which degrades host and viral RNA, and 2'-5'-linked cGAMP activates downstream signaling pathways to induce de novo antiviral gene expression.

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