TREX1 (human) (rec.) (His) (active) (1µg)

Specifications / Handling

More Information
Product Details
Synonyms	Three-prime Repair Exonuclease 1
Product Type	Protein
Properties
Source/Host	Baculovirus system
Sequence	Recombinant human TREX1 enzyme (aa1-286) fused to a C-terminal His-tag.
Crossreactivity	Human
Biological Activity	The enzyme has been thoroughly validated with Transcreener dAMP Exonuclease Assay Kit. For specific activity please refer to the Certificate of Analysis for each individual enzyme lot.
Purity	≥90% (SDS-PAGE)
Accession Number	Q9NSU2
Formulation	Liquid. In 50mM Tris-HCl pH 8.0, 500mM NaCl, 20% glycerol buffer.
Other Product Data	Uniprot Q9NSU2: TREX1_HUMAN
Shipping and Handling
Shipping	DRY ICE
Short Term Storage	-20°C
Long Term Storage	-80°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -80°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

TREX1 is the major exonuclease responsible for degrading cytosolic DNA, and it plays an important role in preventing aberrant autoimmune responses in normal cells by acting as a checkpoint for the cGAS/STING pathway. It is a 3’-5’ exonuclease that cleaves single bases from the 5’ termini of double stranded or single stranded DNA, releasing deoxynucleoside monophosphates, including deoxy-AMP (dAMP).

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