BellBrook

TREX1 (human) (rec.) (His) (active) (10µg)

CHF 1'227.00
In stock
BBL-2262-C01010 µgCHF 1'227.00
More Information
Product Details
Synonyms Three-prime Repair Exonuclease 1
Product Type Protein
Properties
Source/Host Baculovirus system
Sequence

Recombinant human TREX1 enzyme (aa1-286) fused to a C-terminal His-tag.

Crossreactivity Human
Biological Activity

The enzyme has been thoroughly validated with Transcreener dAMP Exonuclease Assay Kit. For specific activity please refer to the Certificate of Analysis for each individual enzyme lot.

Purity ≥90% (SDS-PAGE)
Accession Number Q9NSU2
Formulation Liquid. In 50mM Tris-HCl pH 8.0, 500mM NaCl, 20% glycerol buffer.
Other Product Data

Uniprot Q9NSU2: TREX1_HUMAN

Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at -80°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

TREX1 is the major exonuclease responsible for degrading cytosolic DNA, and it plays an important role in preventing aberrant autoimmune responses in normal cells by acting as a checkpoint for the cGAS/STING pathway. It is a 3’-5’ exonuclease that cleaves single bases from the 5’ termini of double stranded or single stranded DNA, releasing deoxynucleoside monophosphates, including deoxy-AMP (dAMP).

© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.