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BellBrook
TREX1 (human) (rec.) (His) (active) (10µg)
1227
CHF
CHF 1'227.00
In stock
BBL-2262-C01010 µgCHF 1'227.00
| Product Details | |
|---|---|
| Synonyms | Three-prime Repair Exonuclease 1 |
| Product Type | Protein |
| Properties | |
| Source/Host | Baculovirus system |
| Sequence |
Recombinant human TREX1 enzyme (aa1-286) fused to a C-terminal His-tag. |
| Crossreactivity | Human |
| Biological Activity |
The enzyme has been thoroughly validated with Transcreener dAMP Exonuclease Assay Kit. For specific activity please refer to the Certificate of Analysis for each individual enzyme lot. |
| Purity | ≥90% (SDS-PAGE) |
| Accession Number | Q9NSU2 |
| Formulation | Liquid. In 50mM Tris-HCl pH 8.0, 500mM NaCl, 20% glycerol buffer. |
| Other Product Data |
Uniprot Q9NSU2: TREX1_HUMAN |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -80°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
TREX1 is the major exonuclease responsible for degrading cytosolic DNA, and it plays an important role in preventing aberrant autoimmune responses in normal cells by acting as a checkpoint for the cGAS/STING pathway. It is a 3’-5’ exonuclease that cleaves single bases from the 5’ termini of double stranded or single stranded DNA, releasing deoxynucleoside monophosphates, including deoxy-AMP (dAMP).
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