POLQ Helicase (human) (rec.) (His) (active) (20µg)

Specifications / Handling

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Product Details
Synonyms	DNA Polymerase Theta; DNA Polymerase Eta; POLH
Product Type	Protein
Properties
Source/Host	Insect cells
Sequence	Recombinant human POLQ Helicase enzyme (aa67-894) fused to a C-terminal His-tag.
Crossreactivity	Human
Biological Activity	The enzyme has been thoroughly validated with the Transcreener ADP2 Assay Kit. For specific activity please refer to the Certificate of Analysis for each individual enzyme lot.
Purity	≥90% (SDS-PAGE)
Accession Number	O75417
Formulation	Liquid. In 20mM HEPES, 5mM NaCl, 5% glycerol and 0.5 mM TCEP (pH 7.5).
Other Product Data	Click here for Complete Information from the Original Manufacturer Our product description may differ slightly from the original manufacturers product datasheet.
Shipping and Handling
Shipping	DRY ICE
Short Term Storage	-20°C
Long Term Storage	-80°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -80°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

POLQ (also known as DNA Polymerase Theta), is a multifunctional enzyme with template-dependent DNA polymerase, ATP-dependent helicase, and dNTP-dependent endonuclease activities that play important roles in double-strand break repair. POLQ is synthetically lethal with BRCA-1 and ATM mutations, and the polymerase and ATPase activities are targeted with small molecules for anti-cancer drug discovery.

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