BellBrook

POLQ Helicase (human) (rec.) (His) (active) (20µg)

CHF 851.00
In stock
BBL-2289-C02020 µgCHF 851.00
NEW
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Product Details
Synonyms DNA Polymerase Theta; DNA Polymerase Eta; POLH
Product Type Protein
Properties
Source/Host Insect cells
Sequence

Recombinant human POLQ Helicase enzyme (aa67-894) fused to a C-terminal His-tag.

Crossreactivity Human
Biological Activity

The enzyme has been thoroughly validated with the Transcreener ADP2 Assay Kit. For specific activity please refer to the Certificate of Analysis for each individual enzyme lot.

Purity ≥90% (SDS-PAGE)
Accession Number O75417
Formulation Liquid. In 20mM HEPES, 5mM NaCl, 5% glycerol and 0.5 mM TCEP (pH 7.5).
Other Product Data

Click here for Complete Information from the Original Manufacturer
Our product description may differ slightly from the original manufacturers product datasheet.

Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at -80°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

POLQ (also known as DNA Polymerase Theta), is a multifunctional enzyme with template-dependent DNA polymerase, ATP-dependent helicase, and dNTP-dependent endonuclease activities that play important roles in double-strand break repair. POLQ is synthetically lethal with BRCA-1 and ATM mutations, and the polymerase and ATPase activities are targeted with small molecules for anti-cancer drug discovery.

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