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BellBrook
Enzolution™ POLQ Helicase ATPase TR-FRET Assay System
CHF 0.00
In stock
BBL-3034-TR-1K1000 assaysCHF 726.00
BBL-3034-TR-10K10000 assaysCHF 2'609.00
BBL-3034-TR-100K10 x 10000 assaysINQ
Figure 1: Schematic Overview of the POLQ Helicase ATPase Assay System with the Transcreener® ADP2 Assays.
| Product Details | |
|---|---|
| Synonyms | DNA Polymerase Theta; DNA Polymerase Eta; POLH |
| Product Type | Kit |
| Properties | |
| Application Set | Compound Screening |
| Crossreactivity | Human |
| Quantity |
1000 assays/384wells (BBL-3034-TR-1K) 10000 assays/384wells (BBL-3034-TR-10K) 100000 assays/384wells (BBL-3034-TR-100K) Note: The exact number of assays depends on enzyme reaction conditions. |
| Detection Type | TR-FRET |
| Kit Contains |
- POLQ helicase enzyme (human) (rec.) (His) |
| Other Product Data |
Click here for Complete Information from the Original Manufacturer |
| Declaration | Manufactured by BellBrook Labs. |
| Accession Number | O75417 |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Documents | |
| Manual |
 Download PDF |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
POLQ is synthetically lethal with BRCA-1 and ATM mutations, and both the polymerase and ATPase activities are being targeted with small molecules for anti-cancer drug discovery. The POLQ Helicase ATPase Assay System, when used with the Transcreener ADP2 Assay Kit, provides all reagents required to screen and profile POLQ inhibitors.
The POLQ Helicase Assay System includes enzyme, substrate, assay plates, and buffers required for a POLQ reaction to produce ADP. The Transcreener ADP2 Assay (sold separately), a far-red competitive assay designed for HTS and inhibitor dose-response measurements, measures ADP produced to determine enzymatic activity.
When purchasing the POLQ helicase assay system, it is important to choose the assay system readout corresponding to the TR-FRET configuration of your Transcreener ADP2 Assay Kit!
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