BellBrook

Enzolution™ POLQ Helicase ATPase FP Assay System

CHF 0.00
In stock
BBL-3034-FP-1K1000 assaysCHF 726.00
BBL-3034-FP-10K10000 assaysCHF 2'609.00
BBL-3034-FP-100K10 x 10000 assaysINQ
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Product Details
Synonyms DNA Polymerase Theta; DNA Polymerase Eta; POLH
Product Type Kit
Properties
Application Set Compound Screening
Crossreactivity Human
Quantity

1000 assays/384wells (BBL-3034-FP-1K)

10000 assays/384wells (BBL-3034-FP-10K)

100000 assays/384wells (BBL-3034-FP-100K)

Note: The exact number of assays depends on enzyme reaction conditions.

Detection Type Fluorescent polarization
Kit Contains

- POLQ helicase enzyme (human) (rec.) (His)
- POLQ ssDNA
- Enzyme Assay Buffer A, 10X
- 384-Well Low Volume Assay Plates (Corning#4514; sold under #BBL-2229 or BBL-2230)

Other Product Data

Click here for Complete Information from the Original Manufacturer
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by BellBrook Labs.
Accession Number O75417
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Documents
Manual Download PDF
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

POLQ is synthetically lethal with BRCA-1 and ATM mutations, and both the polymerase and ATPase activities are being targeted with small molecules for anti-cancer drug discovery. The POLQ Helicase ATPase Assay System, when used with the Transcreener ADP2 Assay Kit, provides all reagents required to screen and profile POLQ inhibitors.

The POLQ Helicase ATPase Assay System includes enzyme, substrate, assay plates, and buffers required for a POLQ reaction to produce ADP. The Transcreener ADP2 FP Assay (sold separately) is a far-red, competitive assay that directly measures ADP production to determine enzymatic activity.

When purchasing the POLQ Helicase Assay System, it is important to choose the assay system readout corresponding to the FP configuration of your Transcreener ADP2 Assay Kit!

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