SIRT3 (human) (rec.) (His) (active) (20µg)

Sirtuins (Silent information regulators; SIRTs) deacetylate and/or ADP-ribosylate lysine residues of target proteins in an NAD+-dependent manner. Sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell cycle and apoptosis. Sirtuins, in particular SIRT1, emerged as critical regulators of longevity and aging in several model organisms. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer’s disease are associated with sirtuins. Sirtuin-2 (SIRT2) is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of a-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer’s disease are associated with sirtuins. Selective inhibition of Sirtuin-2 achieves neuroprotection and identifies Sirtuin-2 to be a potential therapeutic avenue in Huntington’s and Parkinson’s disease. Sirtuin-3 (SIRT3) promotes fatty acid oxidation, ATP production and antioxidant defense. It acts as a crucial mediator of metabolic adaptation under conditions such as fasting or caloric restriction. Loss or reduced activity of SIRT3 has been associated with metabolic disorders, aging, and cancer progression, highlighting its importance in maintaining mitochondrial and cellular homeostasis.