Ansatrienin A

CHF 110.00
In stock
BVT-0246-M0011 mgCHF 110.00
More Information
Product Details
Synonyms Mycotrienin I; Antibiotic T 23I
Product Type Chemical


MW 636.8
CAS 82189-03-5
RTECS AY4553220
Source/Host Chemicals Isolated from Streptomyces collinus.
Purity Chemicals ≥98% (HPLC)
Appearance Yellow powder.
Solubility Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
Identity Determined by 1H-NMR.
Declaration Manufactured by BioViotica.
Smiles CO[C@@H]1CC(=O)NC2=CC(=O)C=C(CC\C=C(C)/[C@H](O)[C@@H](C)[C@H](C\C=C\C=C\C=C\1)OC(=O)[C@@H](C)NC(=O)C1CCCCC1)C2=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light when in solution.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
After reconstitution protect from light at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Antibiotic.
  • Antitumor compound. Active against several cell lines. Shown to potentiate several clinical anti-cancer agents.
  • Inhibits TNF-α-induced expression of ICAM-1 (IC50=570nM).
  • Antifungal.
  • Inhibits osteoclastic bone resorption.
Product References
  1. Mycotrienin, a new polyene antibiotic isolated from Streptomyces: C. Coronelli, et al.; J. Antibiot. (Tokyo) 20, 329 (1967)
  2. Die Konstitution der fungistatischen Ansamycin-Antibiotica Ansatrienin A und B: M. Damberg, et al.; Tetrahedron Lett. 23, 59 (1982)
  3. Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1460 (1982)
  4. Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1467 (1982)
  5. Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols: M. Kuwano, et al.; Gann. 74, 759 (1983)
  6. Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption: D. Feuerbach, et al.; J. Biol. Chem. 270, 25949 (1995)
  7. (+)-trienomycin A, B, C, and F and (+)-mycotrienins I and II: relative and absolute stereochemistry: A. B. Smith, et al.; JACS 118, 8308 (1996)
  8. Total syntheses of (+)-trienomycins A and F via a unified strategy: A. B. Smith, et al.; JACS 118, 8316 (1996)
  9. Total synthesis of (+)-mycotrienol and (+)-mycotrienin I: application of asymmetric crotylsilane bond constructions: C. E. Masse, et al.; JACS 120, 4123-4134 (1998)
  10. Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines: Y. Yamada, et al.; J. Antibiot. 64, 361 (2011)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.