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BioViotica
Psicofuranine
95
CHF
CHF 95.00
In stock
BVT-0284-M0011 mgCHF 95.00
BVT-0284-M0055 mgCHF 380.00
| Product Details | |
|---|---|
| Synonyms | Angustmycin C; U-9586; 9-β-D-Psicofuranosyl-9H-purin-6-amine |
| Product Type | Chemical |
| Properties | |
| Formula |
C11H15N5O5 |
| MW | 297.3 |
| Merck Index | 14: 7923 |
| CAS | 1874-54-0 |
| Source/Host Chemicals | Isolated from Streptomyces sp. S 2113. |
| Purity Chemicals | ≥98% (HPLC, TLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO; poorly soluble in methanol. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | BNZYRKVSCLSXSJ-IOSLPCCCSA-N |
| Smiles | NC1=NC=NC2=C1N=CN2[C@]1(CO)O[C@H](CO)[C@@H](O)[C@H]1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Nucleoside antibiotic.
- Antitumor compound.
- Xanthosine monophosphate (XMP) aminase inhibitor.
- Antimetabolite of the purine biosynthesis.
Product References
- Studies on angustmycins VIII. The structure of angustmycin C: H. Yüntsen; J. Antibiot. 11A, 244 (1958)
- Psicofuranine I. Discovery, isolation, and properties: T.E. Eble, et al.; Antibiot. Chemother. 9, 419 (1959)
- Psicofuranine. VI. Antitumor and toxicopathological studies: J.S. Evans & J.E. Gray; Antibiot. Chemother. 9, 675 (1959)
- Mechanism of action of psicofuranine: L.J. Hanka; J. Bacteriol. 80, 30 (1960)
- Inhibition of parental and mutant xanthosine 5'-phosphate aminases by psicofuranine: S. Udaka & H.S. Moyed; J. Biol. Chem. 238, 2797 (1963)
- Formation of an adenylxanthosinemonophosphate intermediate by xanthosine 5'-phosphate aminase and its inhibition by psicofuranine: T.T. Fukuyama; J. Biol. Chem. 241, 4745 (1966)
- Nucleoside antibiotics: structure, biological activity, and biosynthesis: K. Isono; J. Antibiot. 41, 1711 (1988), (Review)
- Role of purine biosynthetic intermediates in response to folate stress in Escherichia coli: C.E. Rohlman & R.G. Matthews; J. Bacteriol. 172, 7200 (1990)
- Plasmodium falciparum: isolation and characterisation of a gene encoding protozoan GMP synthase: G.A. McConkey; Exp. Parasitol. 94, 23 (2000)
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