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BioViotica
Aureothricin
50
CHF
CHF 50.00
In stock
BVT-0345-C500500 µgCHF 50.00
BVT-0345-M0011 mgCHF 110.00
| Product Details | |
|---|---|
| Synonyms | Propionylpyrrothione; Farcinicin; N-(4-Methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)propionamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C9H10N2O2S2 |
| MW | 242.3 |
| CAS | 574-95-8 |
| Source/Host Chemicals | Isolated from Streptomyces thioluteus. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Yellow powder. |
| Solubility | Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | UGZYFXMSMFMTSM-UHFFFAOYSA-N |
| Smiles | CCC(=O)NC1=C2SSC=C2N(C)C1=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic.
- Active against Gram-positive and Gram-negative bacteria, yeast, filamentous fungi, protozoa and insects.
- Potent bacterial and yeast RNA polymerases inhibitor.
- Inhibitor of fungal mannan and glucan formation.
- Similar to thiolutin.
- Antitumor compound.
Product References
- The structures of thiolutin and aureothricin, antibiotics containing a unique pyrrolinonodithiole nucleus: W. D. Celmer & I. A. Solomons; J. Am. Chem. Soc. 77, 2861 (1955)
- Anticancer properties of dithiolopyrrolones: J.M. Webster, et al.; US Patent 6,020,360, (2000)
- Thiolutin, an inhibitor of huvec adhesion to vitronectin, reduces paxillin in huvecs and suppresses tumor cell-induced angiogenesis: K. Minamiguchi et al.; Int. J. Cancer 93, 307 (2001)
- Expedient total synthesis of pyrrothine natural products and analogs: T. Hjelmgaard et al.; Org. Biomol. Chem. 5, 344 (2007)
- Dithiolopyrrolone antibiotic formation induced by adding valeric acid to the culture broth of Saccharothrix algeriensis: R. Merrouche et al.; J. Nat. Prod. 73, 1164 (2010)
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