|Synonyms||Natural Yellow 18; Berberinium chloride; BBR; Umbellatine; Majarine; Thalsine|
|Formula||C20H17NO4 . HCl|
|MW||335.3 . 36.5|
|Purity Chemicals||≥98% (TLC)|
|Appearance||Yellow to orange powder.|
|Solubility||Soluble in DMSO or methanol. Slightly soluble in ethanol or water.|
|Identity||Determined by NMR.|
|Declaration||Manufactured by Chemodex.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||+4°C|
Keep cool and dry.
Protect from light and moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at +4°C.|
|Product Specification Sheet|
Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetic, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK.
(1) P.J. Kaboli, et al.; Eur. J. Pharmacol. 740, 584 (2014) | (2) L.M. Ortiz, et al.; Molecules 19, 12349 (2014) | (3) W.J. Ni, et al.; Eur. J. Pharmacol. 760, 103 (2015) | (4) C.J. Yu, et al.; J. Alzheimers Dis. 22, 257 (2010)