Berberine chloride

Specifications / Handling

More Information
Product Details
Synonyms	Natural Yellow 18; Berberinium chloride; BBR; Umbellatine; Majarine; Thalsine
Product Type	Chemical
Properties
Formula	C₂₀H₁₇NO₄ . HCl
MW	335.3 . 36.5
CAS	633-65-8
Source/Host Chemicals	Synthetic
Purity Chemicals	≥98% (TLC)
Appearance	Yellow to orange powder.
Solubility	Soluble in DMSO or methanol. Slightly soluble in ethanol or water.
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	VKJGBAJNNALVAV-UHFFFAOYSA-M
Smiles	[Cl-].COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C1=CC2=C(OCO2)C=C1CC3
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetic, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK.

Potent, uncompetitive, reversible IDO1 inhibitor with IC₅₀ values of 7 μM (cell-based assay) and 9.3 μM (enzymatic assay), and K_i value 8μM.

Inhibits BAFF production in H. pylori-induced chronic gastritis.

Product References

(1) P.J. Kaboli, et al.; Eur. J. Pharmacol. 740, 584 (2014) | (2) L.M. Ortiz, et al.; Molecules 19, 12349 (2014) | (3) W.J. Ni, et al.; Eur. J. Pharmacol. 760, 103 (2015) | (4) C.J. Yu, et al.; J. Alzheimers Dis. 22, 257 (2010)

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