Berberine chloride

CHF 61.00
In stock
CDX-B0212-G01010 gCHF 61.00
CDX-B0212-G02525 gCHF 122.00
CDX-B0212-G05050 gCHF 204.00
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Product Details
Synonyms Natural Yellow 18; Berberinium chloride; BBR; Umbellatine; Majarine; Thalsine
Product Type Chemical
Formula C20H17NO4 . HCl
MW 335.3 . 36.5
CAS 633-65-8
Source/Host Chemicals Synthetic
Purity Chemicals ≥98% (TLC)
Appearance Yellow to orange powder.
Solubility Soluble in DMSO or methanol. Slightly soluble in ethanol or water.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Smiles [Cl-].COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C1=CC2=C(OCO2)C=C1CC3
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetic, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK.

Potent, uncompetitive, reversible IDO1 inhibitor with IC50 values of 7 μM (cell-based assay) and 9.3 μM (enzymatic assay), and Ki value 8μM.
Inhibits BAFF production in H. pylori-induced chronic gastritis.
Product References

(1) P.J. Kaboli, et al.; Eur. J. Pharmacol. 740, 584 (2014) | (2) L.M. Ortiz, et al.; Molecules 19, 12349 (2014) | (3) W.J. Ni, et al.; Eur. J. Pharmacol. 760, 103 (2015) | (4) C.J. Yu, et al.; J. Alzheimers Dis. 22, 257 (2010)

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