|Synonyms||Phenyl N-t-butylnitrone; N-tert-Butyl-α-phenylnitrone; N-Benzylidene-N-(2-methyl-2-propanyl)amine oxide; (Z)-N-Benzylidene-2-methylpropan-2-amine oxide|
|Purity Chemicals||≥98% (GC)|
|Appearance||Off-white to white crystals.|
|Solubility||Soluble in DMSO.|
|Identity||Determined by NMR.|
|Declaration||Manufactured by Chemodex.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Keep cool and dry.
Protect from light and moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
Cell permeable spin trap commonly used in free radical research for both in vivo and in vitro studies. It protects against oxidative damage caused by various inflammatory events, demonstrating neuroprotective, anti-anging, and antidiabetic effects. PBN has been shown to inhibit LPS-induced NF-κB DNA binding activity, inhibit COX-2 catalytic activity, inhibit lipid peroxidation in rat liver microsomes and prevent the induction of inducible nitric oxide synthase (iNOS). Shows anti-cancer activity in several experimental cancer models.
(1) R.A. Floyd; FASEB J. 4, 2587-4597 (1990) | (2) R.F. Haseloff; FEBS Lett. 418, 73 (1997) | (3) R.A. Floyd; Adv. Pharmacol. 38, 361 (1997) | (4) T. Miyajima & Y. Kotake; Free Radic. Biol. Med. 22, 463 (1997) | (5) Y. Kotake, et al.; Biochim. Biophys. Acta 1448, 77 (1998) | (6) R.A. Floyd; Proc. Soc. Exp. Biol. Med. 222, 236 (1999) (Review) | (7) Y. Kotake; Antioxid. Redox Signal. 1, 481 (1999) (Review) | (8) E. Ho, et al.; Free Radic. Biol. Med. 28, 604 (2000) | (9) P. Kelicen, et al.; Neuroreport 13, 1057 (2002) | (10) W.N. Hassan, et al.; Free Radic. Biol. Med. 32, 551 (2002) | (11) K. Saito & H. Yoshioka; Free Radic. Res. 36, 143 (2002) | (12) R.A Floyd; Anticanc. Agents Med. Chem. 11, 373 (2011)