N-tert-Butyl-alpha-phenylnitrone [PBN]

CHF 57.00
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CDX-B0269-G0011 gCHF 57.00
CDX-B0269-G0055 gCHF 230.00
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Product Details
Synonyms Phenyl N-t-butylnitrone; N-tert-Butyl-α-phenylnitrone; N-Benzylidene-N-(2-methyl-2-propanyl)amine oxide; (Z)-N-Benzylidene-2-methylpropan-2-amine oxide
Product Type Chemical
Properties
Formula C11H15NO
MW 177.2
CAS 3376-24-7
RTECS TX1760000
Source/Host Chemicals Synthetic.
Purity Chemicals ≥98% (GC)
Appearance Off-white to white crystals.
Solubility Soluble in DMSO.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key IYSYLWYGCWTJSG-UHFFFAOYSA-N
Smiles CC(C)(C)[N+](\[O-])=C\C1=CC=CC=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Cell permeable spin trap commonly used in free radical research for both in vivo and in vitro studies. It protects against oxidative damage caused by various inflammatory events, demonstrating neuroprotective, anti-anging, and antidiabetic effects. PBN has been shown to inhibit LPS-induced NF-κB DNA binding activity, inhibit COX-2 catalytic activity, inhibit lipid peroxidation in rat liver microsomes and prevent the induction of inducible nitric oxide synthase (iNOS). Shows anti-cancer activity in several experimental cancer models.

Product References

(1) R.A. Floyd; FASEB J. 4, 2587-4597 (1990) | (2) R.F. Haseloff; FEBS Lett. 418, 73 (1997) | (3) R.A. Floyd; Adv. Pharmacol. 38, 361 (1997) | (4) T. Miyajima & Y. Kotake; Free Radic. Biol. Med. 22, 463 (1997) | (5) Y. Kotake, et al.; Biochim. Biophys. Acta 1448, 77 (1998) | (6) R.A. Floyd; Proc. Soc. Exp. Biol. Med. 222, 236 (1999) (Review) | (7) Y. Kotake; Antioxid. Redox Signal. 1, 481 (1999) (Review) | (8) E. Ho, et al.; Free Radic. Biol. Med. 28, 604 (2000) | (9) P. Kelicen, et al.; Neuroreport 13, 1057 (2002) | (10) W.N. Hassan, et al.; Free Radic. Biol. Med. 32, 551 (2002) | (11) K. Saito & H. Yoshioka; Free Radic. Res. 36, 143 (2002) | (12) R.A Floyd; Anticanc. Agents Med. Chem. 11, 373 (2011)

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