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Chemodex
Colcemid
299
CHF
CHF 299.00
In stock
CDX-C0022-M02525 mgCHF 299.00
| Product Details | |
|---|---|
| Synonyms | Demecolcine; N-Deacetyl-N-methylcolchicine |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H25NO5 |
| MW | 371.43 |
| CAS | 477-30-5 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Light yellow powder. |
| Solubility | Soluble in chloroform. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | NNJPGOLRFBJNIW-HNNXBMFYSA-N |
| Smiles | O=C1C(OC)=CC=C(C([C@@H](NC)CC2)=C1)C3=C2C=C(OC)C(OC)=C3OC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Depolymerizes microtubules and blocks mitosis at metaphase. Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.
Product References
(1) K. Ray et al.; Eur. J. Biochem. 142, 577 (1984)
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