Chemodex

Capsaicin from Capsicum annuum

CHF 61.00

In stock

CDX-C0941-M05050 mgCHF 61.00

CDX-C0941-M250250 mgCHF 244.00

CDX-C0941-G0011 gCHF 516.00

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Product Details
Synonyms	8-Methyl-N-vanillyl-trans-6-nonenamide; N-[(4-hydroxy-3-methoxyphenyl)methyl]-6E-8-methyl-nonenamide; NSC 56353
Product Type	Chemical
Properties
Formula	C₁₈H₂₇NO₃
MW	305.41
CAS	404-86-4
Source/Host Chemicals	Isolated from Capsicum annuum.
Purity Chemicals	≥95%
Appearance	White crystalline solid.
Solubility	Soluble in ethanol, benzene, ether or chloroform.
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	YKPUWZUDDOIDPM-SOFGYWHQSA-N
Smiles	COC1=C(O)C=CC(CNC(=O)CCCC\C=C\C(C)C)=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+20°C
Long Term Storage	+4°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Primary active component of the heat and pain-eliciting lipid-soluble fraction of Capsicum pepper. Acts as an agonist at the vanilloid receptor (VR1; TRPV1) receptor, a ligand-gated non-selective cation channel. Capsaicin elicits a sensation of burning pain by activation of TRPV1 on small, non-myelinated polymodal C-type nociceptive nerve fibers. It has been shown to have antinociceptive, anti-inflammatory, anti-obesity, neuroprotective and anticancer effects.

Product References

(1) P.G. Hoffman, et al.; J. Agric. Food Chem. 31, 1326 (1983) | (2) P.M. Gannett, et al.; J. Org. Chem. 53, 1064 (1988) | (3) B. Lynn; Pain 41, 61 (1990) | (4) P. Holzer; Adv. Exp. Med. Biol. 298, 3 (1991) | (5) Y.J. Surh & S.S. Lee; Life Sci. 56, 1845 (1995) | (6) M.J. Caterina, et al.; Nature 389, 816 (1997) | (7) S.C. Pingle, et al.; Handb. Exp. Pharmacol. 179, 155 (2007) | (8) S.J. Conway; Chem. Soc. Rev. 37, 1530 (2008) | (9) F.W. Leung; Prog. Drug Res. 68, 171 (2014) | (10) Y. Deng, et al.; Autoimmun. Rev. (2016)

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