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Chemodex
Dihydrofluorescein diacetate
110
CHF
CHF 110.00
In stock
CDX-D0122-G0011 gCHF 110.00
CDX-D0122-G01010 gCHF 414.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula | C24H18O7 |
| MW | 418.4 |
| CAS | 35340-49-9 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥97% (NMR) |
| Appearance | Solid. |
| Solubility | Soluble in chloroform. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | YKSJJXGQHSESKB-UHFFFAOYSA-N |
| Smiles | CC(=O)OC1=CC2=C(C=C1)C(C1=C(O2)C=C(OC(C)=O)C=C1)C1=C(C=CC=C1)C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Dihydrofluorescein diacetate is a fluorescent probe for detecting intracellular oxidants. It is hydrolyzed by cellular esterases to dihydrofluorescein and is then oxidized to fluorescein primarily by H2O2. Dihydrofluorescein diacetate might be reactive toward a broad range of oxidizing reactions that may be increased during intracellular oxidant stress. Cell-loading studies indicate that dihydrofluorescein achieves higher intracellular concentrations than the other redox sensors such as Dihydrorhodamine 123 (Ex/Em: 490/514nm).
Product References
(1) P.P. Williams & R.L. Stolzenberg; Applied Microbiology 23(4), 745-9 (1972) | (2) S.L. Hempel, et al.; Free Radical Biology & Medicine 27(1/2), 146-159 (1999) | (3) Y. O'Malley et al.; Free Radical Biology & Medicine 36(1), 90-100 (2004)
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