7β-Hydroxycholesterol

CHF 153.00
In stock
CDX-H0116-M0055 mgCHF 153.00
CDX-H0116-M01010 mgCHF 255.00
CDX-H0116-M100100 mgCHF 1'212.00
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Product Details
Synonyms 5-Cholestene-3β,7β-diol
Product Type Chemical
Properties
Formula C27H46O2
MW 402.65
CAS 566-27-8
Source/Host Chemicals Synthetic
Purity Chemicals ≥98% (HPLC)
Appearance White to white-yellow powder.
Solubility Soluble in ethanol, chloroform or methanol.
Identity Determined by NMR.
Declaration Manufactured by Chemodex.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

InChi Key OYXZMSRRJOYLLO-KGZHIOMZSA-N
Smiles [H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Oxysterole. Cholesterol oxidation metabolite. Induces cell death/apoptosis and shows antiproliferative activity against cancer cells, involving mitochondrial perturbation, oxidative stress and lysosomal destabilization. Its membrane organizing properties may have implications in Alzheimer’s disease. Increased levels correlate with risk of cardiovascular diseases including atherosclerosis. Shown to have proinflammatory activity.

Product References

(1) S. Lemaire, et al.; FEBS Lett. 440, 434 (1998) | (2) G. Lizard, et al.; Arterioscler. Thromb. Vasc. Biol. 19, 1190 (1999) | (3) J. Wang, et al.; Biochem. 43, 1010 (2004) | (4) S. Roussi, et al.; Cell Death Differ. 12, 128 (2005) | (5) K.A. Kang, et al.; Biol. Pharm. Bull. 28, 1377 (2005) | (6) S. Roussi, et al.; Apoptosis 12, 87 (2007) | (7) S. Lordan, et al.; Int. J. Toxicol. 27, 279 (2008) | (8) W. Li, et al.; Free Radic. Res. 43, 1072 (2009) | (9) L. Trevisi, et al.; J. Vasc. Res. 47, 241 (2010) | (10) C. Mascia, et al.; Free Radic. Biol. Med. 49, 2049 (2010)

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