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Chimerigen
IL-17A (human):Fc (human) (rec.)
500
CHF
CHF 500.00
In stock
CHI-AG-40A-0066-C05050 µgCHF 500.00
| Product Details | |
|---|---|
| Synonyms | Interleukin-17A; Cytotoxic T-lymphocyte-associated Antigen 8; CTLA-8 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The extracellular domain of human IL-17A (aa 24-155) is fused at the C-terminus to the Fc portion of human IgG1. |
| Crossreactivity | Human |
| MW | ~42kDa (SDS-PAGE) |
| Purity | ≥90% (SDS-PAGE) |
| Endotoxin Content | <0.06EU/μg purified protein (LAL test; Lonza). |
| Reconstitution |
Reconstitute with sterile water to a concentration of 1mg/ml. Add 1x PBS to the desired protein concentration. |
| Formulation | Lyophilized from 0.2μm-filtered solution in 1X PBS. |
| Protein Negative Control | |
| Other Product Data |
NCBI link AAH67505.1: Interleukin-17A (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Interleukin-17A (IL-17A) exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-κB and costimulation of T cell proliferation. Induces stromal cells to produce proinflammatory and hematopoietic cytokines.
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