IL-17A (human):Fc (human) (rec.) (non-lytic)

CHF 380.00
In stock
CHI-HF-22017A-C05050 µgCHF 380.00
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Product Details
Synonyms Interleukin-17A; Cytotoxic T-lymphocyte-associated Antigen 8; CTLA-8
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence

The extracellular domain of human IL-17A (aa 20-155) is fused to the N-terminus of the Fc region of mutant human IgG1.

Crossreactivity Human
Biological Activity

Measured by its ability to induce IL-6 secretion.

MW ~42kDa (SDS-PAGE)
Purity ≥98% (SDS-PAGE)
Endotoxin Content <5EU/mg purified protein (LAL test; Lonza).
Reconstitution Reconstitute 50µg vial with 50 µl sterile water to a concentration of 1mg/ml.
Add 1X PBS to the desired protein concentration.
Formulation Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control

Fc (human) IgG1 Control (rec.) (non-lytic)

Other Product Data

NCBI reference AAH67505.1: IL-17A (human)

Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Interleukin-17A (IL-17A) exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblsts, the enhancement of surface expression of ICAM-1 in fibroblast, activation of NF-κB and costimulation of T cell proliferation. Induces stromal cells to produce proinflammatory and hematopoietic cytokines.

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