IL-17A (human):Fc (human) (recombinant protein) (non-lytic)

Specifications / Handling

More Information
Product Details
Synonyms	Interleukin-17A; Cytotoxic T-lymphocyte-associated Antigen 8; CTLA-8
Product Type	Protein
Properties
Source/Host	HEK 293 cells
Sequence	The extracellular domain of human IL-17A (aa 20-155) is fused to the N-terminus of the Fc region of mutant human IgG1.
Crossreactivity	Human
Biological Activity	Measured by its ability to induce IL-6 secretion.
MW	~42kDa (SDS-PAGE)
Purity	≥98% (SDS-PAGE)
Endotoxin Content	<5EU/mg purified protein (LAL test; Lonza).
Reconstitution	Reconstitute 50µg vial with 50 µl sterile water to a concentration of 1mg/ml. Add 1X PBS to the desired protein concentration.
Formulation	Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control	Fc (human) IgG1 Control (rec.) (non-lytic)
Other Product Data	NCBI reference AAH67505.1: IL-17A (human)
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Interleukin-17A (IL-17A) exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblsts, the enhancement of surface expression of ICAM-1 in fibroblast, activation of NF-κB and costimulation of T cell proliferation. Induces stromal cells to produce proinflammatory and hematopoietic cytokines.

Call	+41 61 926 6040
Fax	+41 61 926 6049

IL-17A (human):Fc (human) (rec.) (non-lytic)