IL-17A (human):Fc (human) (rec.) (non-lytic)
|Synonyms||Interleukin-17A; Cytotoxic T-lymphocyte-associated Antigen 8; CTLA-8|
|Source/Host||HEK 293 cells|
The extracellular domain of human IL-17A (aa 20-155) is fused to the N-terminus of the Fc region of mutant human IgG1.
Measured by its ability to induce IL-6 secretion.
|Endotoxin Content||<5EU/mg purified protein (LAL test; Lonza).|
Reconstitute 50µg vial with 50 µl sterile water to a concentration of 1mg/ml.
Add 1X PBS to the desired protein concentration.
|Formulation||Lyophilized from 0.2μm-filtered solution in PBS.|
|Protein Negative Control|
|Other Product Data||
NCBI reference AAH67505.1: IL-17A (human)
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
|Product Specification Sheet|
Interleukin-17A (IL-17A) exhibits multiple biological activities on a variety of cells including the induction of IL-6 and IL-8 production in fibroblsts, the enhancement of surface expression of ICAM-1 in fibroblast, activation of NF-κB and costimulation of T cell proliferation. Induces stromal cells to produce proinflammatory and hematopoietic cytokines.