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Chimerigen
IL-12 (human):Fc (human) (rec.)
470
CHF
CHF 470.00
In stock
CHI-HF-21012-C02525 µgCHF 470.00
| Product Details | |
|---|---|
| Synonyms | Interleukin-12; IL-12p70; IL-12p75; Cytotoxic Lymphocyte Maturation Factor; CLMF; NKSF; Natural Killer Cell Stimulatory Factor; TSF; T-cell Stimulatory Factor |
| Product Type | Protein |
| Properties | |
| Source/Host | CHO cells |
| Sequence |
The human IL-12 complex composed of the p40 subunit (aa 23-328) and the p35 subunit (aa 57-253) is fused through a polypeptide linker to the Fc region of human IgG1. |
| Crossreactivity | Human |
| MW | ~100-150kDa. |
| Purity | ≥98% (SDS-PAGE) |
| Endotoxin Content | <1EU/mg protein (LAL test; Lonza). |
| Reconstitution | Reconstitute at 100μg/ml in sterile PBS. |
| Formulation | Lyophilized from 0.2μm-filtered solution in PBS. |
| Protein Negative Control | |
| Other Product Data |
NCBI reference NP_002178.2: IL-12 p40 subunit (human) NCBI reference NP_000873.2: IL-12 p35 subunit (human) |
| Declaration | Manufactured by Chimerigen. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Interleukin-12 (IL-12), also known as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and Natural Killer (NK) cells. Some of these IL-12 activities include the induction of IFN-γ and TNF in resting and activated T and NK cells; the enhancement of cytotoxic activity of resting NK and T cells, the stimulation of resting T cell proliferation in the presence of a comitogen; and the enhancement of NK cell proliferation. Current evidence indicates that IL-12 is a key mediator of cellular immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been suggested that IL-12 may have therapeutic potential as a vaccine adjuvant that promotes cellular immunity and as an antitumor and anti viral agent.
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