anti-Crotonaldehyde [CRA], mAb (82D3)
|Product Type||Monoclonal Antibody|
|Immunogen/Antigen||CRA-modified keyhole-lympet hemocyanine.|
Immunohistochemistry: Recommended concentration is 0.5-1μg/mL on paraffin sections.
Recognizes CRA-modified proteins (especially CRA-lysine adducts).
|Purity Detail||Protein A purified.|
|Formulation||Frozen liquid. Contains 10mM PBS, 0.1% NaN3 and 0.5% BSA.|
|Isotype Negative Control|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
|Declaration||Manufactured by JaICA.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Avoid freeze/thaw cycles.|
|Use/Stability||Stable for at least 3 years after receipt when stored at -20°C.|
|Product Specification Sheet|
Crotonaldehyde (CRA) is a representative carcinogenic aldehyde formed endogenously through lipid peroxidation. CRA is highly reactive aldehyde and reacts with lysine residue in protein. The reaction with CRA and lysine residue leads to the formation of numerous numbers of adducts.
- Endogenous formation of protein adducts with carcinogenic aldehydes: K. Ichihashi, et al.; J. Biol. Chem. 276, 23903 (2001)