JaICA

anti-4-Hydroxy-2-hexenal [4-HHE], mAb (HHE53)

CHF 1'035.00

In stock

JAI-MHH-030N30 µgCHF 1'035.00

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Product Details
Product Type	Monoclonal Antibody
Properties
Clone	HHE53
Isotype	Mouse IgG1κ
Source/Host	Ascites
Immunogen/Antigen	HHE-modified keyhole-lympet hemocyanine.
Application	Immunohistochemistry: Recommended concentration is 0.5-1μg/mL on paraffin sections.
Crossreactivity	All Human
Specificity	Recognizes HHE-modified proteins (especially HHE-His Michael adducts).
Purity Detail	Protein A purified.
Formulation	Frozen liquid. Contains 10mM PBS, 0.1% NaN3 and 0.5% BSA.
Isotype Negative Control	Mouse IgG1 Isotype Control
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by JaICA.
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 3 years after receipt when stored at -20°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

4-hydroxy-2-alkenal is one of the major lipid peroxidation products, and shows many biological effects such as high toxicity to cells. Among them, 4-hydroxy-2-hexenal (HHE) is an aldehyde formed during peroxidation of n-3 fatty acids such as docosahexaenoic acid. HHE is highly reactive aldehyde and reacts with histidine residue of protein to form Michael-addition type adducts.

Product References

Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids: S. Yamada, et al.; J. Lipid. Res. 45, 626 (2004)
Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateralsclerosis: N. Shibata, et al.; Brain Res. 1019, 170 (2004)

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