anti-Nitrotryptophan (NW), mAb (117C)

CHF 239.00
In stock
JAI-MNW-020P20 µgCHF 239.00
 
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Product Details
Product Type Monoclonal Antibody
Properties
Clone 117C
Isotype Mouse IgG1κ
Immunogen/Antigen 6-Nitrotryptophan modified Keyhole Limpet Hemocyanin (KLH).
Application Immunohistochemistry
Western blot
ELISA
Crossreactivity All
Human
Specificity Recognizes 6-Nitrotryptophan.
Purity Protein A purified.
Concentration 100μg/ml of IgG in 10mM PBS (pH 7.4).
Formulation Lyophilized.
Reconstitution Reconstitute with 200 μl distilled water.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by JaICA.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 3 years after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Reactive nitrogen species (RNS) are formed in a variety of diseases such as atherosclerosis, inflammation, cancer and neurodegenerative diseases. Peroxinitrite (ONOO-) is known as a potent biological oxidant, which is formed via very fast reaction between nitric oxide (NO) and superoxide (O2-). Peroxinitrite can induce nitration of aromatic amino acids such as Tyr, Trp, Phe and His, which results in modulation of protein functions. To date, 6-nitrotryptophan (6-NO2-Trp) is shown to be one of the most stable and major peroxynitrite-modified amino acids, and growing evidences suggest that nitrotryptophan may play a significant role in the cellular regulation under nitrosative stress. This antibody is suitable for immunohistochemistry, western blotting and ELISA and may provide a powerful tool for the investigation of nitrosative stress inside living bodies.
Product References
  1. Proteomic analysis of endogeneous nitrotryptophan-containing proteins in rat hippocampus and cerebellum: M. Uda, et al.; Bioci. Rep. 32, 521 (2012)
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