anti-Nitrotryptophan (NW), mAb (117C)
JAI-MNW-020P20 µgCHF 239.00
Chemical structure of 6-Nitrotryptophan.
|Product Type||Monoclonal Antibody|
|Immunogen/Antigen||6-Nitrotryptophan modified Keyhole Limpet Hemocyanin (KLH).|
|Purity||Protein A purified.|
|Concentration||100μg/ml of IgG in 10mM PBS (pH 7.4).|
|Reconstitution||Reconstitute with 200 μl distilled water.|
|Other Product Data||
Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
|Declaration||Manufactured by JaICA.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Avoid freeze/thaw cycles.|
|Use/Stability||Stable for at least 3 years after receipt when stored at -20°C.|
|Product Specification Sheet|
Reactive nitrogen species (RNS) are formed in a variety of diseases such as atherosclerosis, inflammation, cancer and neurodegenerative diseases. Peroxinitrite (ONOO-) is known as a potent biological oxidant, which is formed via very fast reaction between nitric oxide (NO) and superoxide (O2-). Peroxinitrite can induce nitration of aromatic amino acids such as Tyr, Trp, Phe and His, which results in modulation of protein functions. To date, 6-nitrotryptophan (6-NO2-Trp) is shown to be one of the most stable and major peroxynitrite-modified amino acids, and growing evidences suggest that nitrotryptophan may play a significant role in the cellular regulation under nitrosative stress. This antibody is suitable for immunohistochemistry, western blotting and ELISA and may provide a powerful tool for the investigation of nitrosative stress inside living bodies.
- Proteomic analysis of endogeneous nitrotryptophan-containing proteins in rat hippocampus and cerebellum: M. Uda, et al.; Bioci. Rep. 32, 521 (2012)