anti-Nitrotryptophan (NW), mAb (117C)

CHF 240.00
In stock
JAI-MNW-020P20 µgCHF 240.00
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Product Details
Product Type Monoclonal Antibody
Clone 117C
Isotype Mouse IgG1κ
Immunogen/Antigen 6-Nitrotryptophan modified Keyhole Limpet Hemocyanin (KLH).

Western blot

Crossreactivity All

Recognizes 6-Nitrotryptophan.

Purity Protein A purified.
Concentration 100μg/ml of IgG in 10mM PBS (pH 7.4).
Formulation Lyophilized.
Reconstitution Reconstitute with 200 μl distilled water.
Isotype Negative Control

Mouse IgG1 Isotype Control

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by JaICA.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 3 years after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Reactive nitrogen species (RNS) are formed in a variety of diseases such as atherosclerosis, inflammation, cancer and neurodegenerative diseases. Peroxinitrite (ONOO-) is known as a potent biological oxidant, which is formed via very fast reaction between nitric oxide (NO) and superoxide (O2-). Peroxinitrite can induce nitration of aromatic amino acids such as Tyr, Trp, Phe and His, which results in modulation of protein functions. To date, 6-nitrotryptophan (6-NO2-Trp) is shown to be one of the most stable and major peroxynitrite-modified amino acids, and growing evidences suggest that nitrotryptophan may play a significant role in the cellular regulation under nitrosative stress. This antibody is suitable for immunohistochemistry, western blotting and ELISA and may provide a powerful tool for the investigation of nitrosative stress inside living bodies.

Product References
  1. Proteomic analysis of endogeneous nitrotryptophan-containing proteins in rat hippocampus and cerebellum: M. Uda, et al.; Bioci. Rep. 32, 521 (2012)
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