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RevMab
anti-Symmetric Dimethyl-Histone H4 (Arg3), Rabbit Monoclonal (RM459)
251
CHF
CHF 251.00
In stock
REV-31-1351-00-C02525 µgCHF 251.00
REV-31-1351-00-C100100 µgCHF 559.00
Figure 1: Western Blot of acid extracts of K562 cells (1) and recombinant histone H4 (2), using anti-Symmetric Dimethyl-Histone H4 (Arg3) Rabbit monoclonal mntibody (Clone RM459) at 0.1 µg/mL.
| Product Details | |
|---|---|
| Synonyms | H4 R3me2 |
| Product Type | Recombinant Antibody |
| Properties | |
| Clone | RM459 |
| Isotype | Rabbit IgG |
| Source/Host | Rabbit |
| Immunogen/Antigen | A symmetric dimethyl-peptide corresponding to the symmetric demethylated Histone H4 (Arg3). |
| Application |
Western Blot: 0.1 µg/ml - 2 µg/ml |
| Crossreactivity |
Human All Vertebrates |
| Specificity |
This antibody reacts to Histone H4 symmetric dimethylated at arginine 3 (R3me2s). No cross-reactivity with unmodified arginine 3, monomethylated or asymmetric dimethylated arginine 3, or other methylated arginine in Histone H4 has been shown. |
| Purity | Protein A purified. |
| Purity Detail | Protein A affinity purified from an animal origin-free culture supernatant. |
| Concentration | 1 mg/ml |
| Formulation | Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Accession Number | P62805 |
| Declaration | Manufactured by RevMab Biosciences. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Histone H4 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H4 is involved with the structure of the nucleosome of the 'beads on a string' organization. Histone proteins are highly post-translationally modified. Covalently bonded modifications include acetylation and methylation of the N-terminal tails. These modifications may alter expression of genes located on DNA associated with its parent histone octamer. Histone H4 is an important protein in the structure and function of chromatin, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.
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