SynKinase

GSK429286A

Name: GSK429286A
Brand: SynKinase
SKU: SYN-1071
Price: 128.00 CHF
Availability: InStock

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Specifications / Handling

More Information
Product Details
Synonyms	GSK-429286A; RHO-15
Product Type	Chemical
Properties
Formula	C₂₁H₁₆F₄N₄O₂
MW	432.4
CAS	864082-47-3
Purity Chemicals	≥95%
Appearance	Solid.
Solubility	Soluble in DMSO.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: ROCK \| Kinase Group: AGC \| Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	OLIIUAHHAZEXEX-UHFFFAOYSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

GSK429286A is a potent and selective inhibitor of Rho-associated kinase (ROCK1), with an IC(50) of 14nM. It is orally available and has been shown to dramatically reduce mean arterial pressure in spontaneously hypertensive rats.

Product-specific References

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease: R.J. Nichols, et al.; Biochem. J. 424, 47 (2009)

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