GSK429286A

CHF 108.00
In stock
SYN-1071-M0011 mgCHF 108.00
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More Information
Product Details
Synonyms GSK-429286A; RHO-15
Product Type Chemical
Properties
Formula C21H16F4N4O2
MW 432.4
CAS 864082-47-3
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: ROCK | Kinase Group: AGC | Substrate: Serine-Threonine

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key OLIIUAHHAZEXEX-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
GSK429286A is a potent and selective inhibitor of Rho-associated kinase (ROCK1), with an IC(50) of 14nM. It is orally available and has been shown to dramatically reduce mean arterial pressure in spontaneously hypertensive rats.
Product References
  1. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease: R.J. Nichols, et al.; Biochem. J. 424, 47 (2009)
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