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SynKinase
SR3677
CHF 0.00
In stock
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| Product Details | |
|---|---|
| Synonyms | SR-3677 |
| Product Type | Chemical |
| Properties | |
| Formula | C22H24N4O4 |
| MW | 408.5 |
| CAS | 1072959-67-1 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: RSK | Kinase Group: AGC | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | OQWZIAVXCYIZNN-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively). SR-3677 had an IC(50) of approximately 3nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 non-kinase enzymes and receptors.
Product References
- Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors: Y. Feng, et al.; J. Med. Chem. 51, 6642 (2008)
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