XL019

CHF 227.00
In stock
SYN-1191-M0011 mgCHF 227.00
SYN-1191-M0055 mgCHF 347.00
SYN-1191-M01010 mgCHF 593.00
SYN-1191-M05050 mgCHF 1'778.00
SYN-1191-M100100 mgCHF 2'568.00
 
More Information
Product Details
Synonyms XL-019
Product Type Chemical
Properties
Formula C25H28N6O2
MW 444.5
CAS 945750-13-0
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO.
Declaration Manufactured by SynKinase.
Other Product Data Target: PI3K - mTOR | Kinase Group: Lipid Kinase | Substrate: Lipid

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key ISOCDPQFIXDIMS-HSZRJFAPSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
XL019 is a potent JAK2 inhibitor (IC(50) of 2nM) with excellent selectivity versus the other members of the JAK kinase family (JAK1, IC(50) of 130nM; JAK3, IC(50) of 250nM; TYK2, IC(50) of 340nM).
Product References
  1. SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors: T. Forsyth, et al.; Bioorg. Med. Chem. Lett. 22, 7653 (2012)
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