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AdipoGen Life Sciences
IL-37 (human) (rec.) (His)
240
CHF
CHF 240.00
In stock
AG-40A-0174Y-C01010 µgCHF 240.00
AG-40A-0174Y-30103 x 10 µgCHF 480.00
| Product Details | |
|---|---|
| Synonyms | Interleukin-1 Family Member 7; IL-1F7; FIL1 zeta; IL-1X; Interleukin-1 Homolog 4; IL-1H4; Interleukin-1 zeta; IL-1 zeta; IL-1RP1; IL1F7; FIL1Z, IL1H4, IL1RP1 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence |
Human IL-37 (aa 1-218) is fused at the C-terminus to a His-tag. |
| Crossreactivity | Human |
| MW | ~30kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.05EU/μg purified protein (LAL test; Lonza). |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Other Product Data |
UniProt link Q9NZH6: IL-37 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
IL-37 (IL-1F7; IL-1H4) is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells (PBMCs) and dendritic cells. IL-37 is an inhibitor of innate immunity with anti-inflammatory properties. It binds to the interleukin-18 receptor (IL-18R) and its co-receptor SIGIRR. IL-37 is secreted as a full-length and as a processed form starting from amino acid Val46. It plays an important role as a link between innate and adaptive immunity and acts as an inhibitor of autoimmune diseases and tumor growth. IL-37 also inhibited Lipopolysaccharide (LPS)-induced immunological reaction and LPS-induced osteoclast formation and bone resorption.
Product References
- Interleukin-37 ameliorates myocardial ischemia/reperfusion injury in mice: B. Wu, et al.; Clin. Exp. Immunol. 176, 438 (2014)
- The evaluation of plasma and leukocytic IL-37 expression in early inflammation in patients with acute ST-segment elevation myocardial infarction after PCI: X. Wang, et al.; Med. Inflamm. 2015, ID626934 (2015)
- The protective effect of Interleukin-37 on vascular calcification and atherosclerosis in apolipoprotein: M. Chai, et al.; J. Interferon Cytok. Res. 35, 530 (2015)
- Interleukin-37 Relieves Allergic Inflammation in a House Dust Mite Allergic Rhinitis Murine Model: D.H. Kim, et al.; Iran J. Allergy Asthma Immunol. 16, 404 (2017)
- Exogenous interleukin 37 ameliorates atherosclerosis via inducing the Treg response in ApoE-deficient mice: Q. Ji, et al.; Nature Sci. Rep. 7, 3310 (2017)
- IL-37 expression is downregulated in lesional psoriasis skin: K. Ronholt, et al.; Immunohorizons 4, 754 (2020)
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