IL-37 (aa 46-218) (human) (rec.) (His)
Lane 1: IL-37 (human) (rec.) (His) (Prod. No. AG-40A-0174)
Lane 2: IL-37 (aa 46-218) (human) (rec.) (His) (Prod. No. AG-40A-0190)
|Synonyms||Interleukin-1 Family Member 7; IL-1F7; FIL1 zeta; IL-1X; Interleukin-1 Homolog 4; IL-1H4; Interleukin-1 zeta; IL-1 zeta; IL-1RP1; IL1F7; FIL1Z, IL1H4, IL1RP1|
|Sequence||Human IL-37 (aa Val46-Asp218) is fused at the C-terminus to a His-tag.|
|Purity Detail||Purified using Ni-NTA column and FPLC.|
|Endotoxin Content||<0.1EU/μg purified protein (LAL test).|
for 10µg size: 0.1mg/ml
for 50µg size: 0.5 mg/ml.
|Reconstitution||Reconstitute with 100µl sterile water.|
|Formulation||Lyophilized from 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.|
|Other Product Data||UniProt link Q9NZH6: IL-37 (human)|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
|Product Specification Sheet|
IL-37 (IL-1F7; IL-1H4) is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells (PBMCs) and dendritic cells. IL-37 is an inhibitor of innate immunity with anti-inflammatory properties. It binds to the interleukin-18 receptor (IL-18R) and its co-receptor SIGIRR. IL-37 is secreted as a full-length and as a processed form starting from amino acid Val46. It plays an important role as a link between innate and adaptive immunity and acts as an inhibitor of autoimmune diseases and tumor growth. IL-37 also inhibited Lipopolysaccharide (LPS)-induced immunological reaction and LPS-induced osteoclast formation and bone resorption.