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AdipoGen Life Sciences
IL-37 (aa 46-218) (human) (rec.) (His)
360
CHF
CHF 360.00
In stock
AG-40A-0190-C01010 µgCHF 360.00
AG-40A-0190-C05050 µgCHF 865.00
Figure 1: NH2-terminal sequence analysis.
Figure 2: SDS Page of full-length and truncated IL-37 (human).
Lane 1: IL-37 (human) (rec.) (His) (Prod. No. AG-40A-0174)
Lane 2: IL-37 (aa 46-218) (human) (rec.) (His) (Prod. No. AG-40A-0190)
Lane 1: IL-37 (human) (rec.) (His) (Prod. No. AG-40A-0174)
Lane 2: IL-37 (aa 46-218) (human) (rec.) (His) (Prod. No. AG-40A-0190)
| Product Details | |
|---|---|
| Synonyms | Interleukin-1 Family Member 7; IL-1F7; FIL1 zeta; IL-1X; Interleukin-1 Homolog 4; IL-1H4; Interleukin-1 zeta; IL-1 zeta; IL-1RP1; IL1F7; FIL1Z, IL1H4, IL1RP1 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence | Human IL-37 (aa Val46-Asp218) is fused at the C-terminus to a His-tag. |
| Crossreactivity | Human |
| MW | ~20kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Purified using Ni-NTA column and FPLC. |
| Endotoxin Content | <0.1EU/μg purified protein (LAL test). |
| Concentration |
After reconstitution: for 10µg size: 0.1mg/ml for 50µg size: 0.5 mg/ml. |
| Reconstitution | Reconstitute with 100µl sterile water. |
| Formulation | Lyophilized from 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. |
| Other Product Data | UniProt link Q9NZH6: IL-37 (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
IL-37 (IL-1F7; IL-1H4) is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells (PBMCs) and dendritic cells. IL-37 is an inhibitor of innate immunity with anti-inflammatory properties. It binds to the interleukin-18 receptor (IL-18R) and its co-receptor SIGIRR. IL-37 is secreted as a full-length and as a processed form starting from amino acid Val46. It plays an important role as a link between innate and adaptive immunity and acts as an inhibitor of autoimmune diseases and tumor growth. IL-37 also inhibited Lipopolysaccharide (LPS)-induced immunological reaction and LPS-induced osteoclast formation and bone resorption.
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