IL-1β (human) ELISA Kit

CHF 650.00
In stock
AG-45B-0021-KI0196 wellsCHF 650.00
More Information
Product Details
Synonyms Interleukin-1β; IL-1F2
Product Type Kit
Properties
Application Set Quantitative ELISA
Specificity

Detects human IL-1β in serum, plasma and cell culture supernatant.

Crossreactivity Human
Quantity

1 x 96 wells

Sensitivity 0.7pg/ml
Range 1.5625 to 100pg/ml
Sample Type Cell Culture Supernatant
Plasma
Serum
Assay Type Sandwich
Detection Type Colorimetric
Other Product Data

UniProt link P01584: Interleukin-1β (human)

Accession Number P01584
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice After standard reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Plate and reagents should reach room temperature before use.
Use/Stability 12 months after the day of manufacturing. See expiry date on ELISA Kit box.
Documents
Manual Download PDF
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF

The interleukin-1 (IL-1) family is a central mediator of innate immunity and inflammation. IL-1 family members are associated with both the development and progression of inflammatory diseases and have been linked to neurodegenerative and neuroinflammatory diseases. The IL-1 family of cytokines has 11 members, which are further subdivided into three groups, the IL-1, IL-18 and IL-36 subfamilies. The IL-1 cytokine subfamily includes agonists (IL-1α, IL-1β and IL-33) as well as receptor antagonist IL-1Ra. IL-1β and IL-1α exert similar biological effects acting on receptor IL-1R, eliciting pro-inflammatory actions. Unlike IL-1α which is both constitutively expressed and active in its 31kDa pro-form, IL-1β is only produced in its inactive 35kDa pro-form following priming signals, such as pathogen- or damage-associated molecular patterns (PAMPs or DAMPs) and is subsequently cleaved to its 17kDa active form following inflammasome activation in damaged or diseased states. IL-1β is expressed by activated macrophages and monocytes. Active IL-1β has known roles in initiating and propagating sterile inflammation, including macrophage recruitment, activation of the pro-inflammatory cytokine interleukin-6 (IL-6) and modulating chemokine expression. IL-1β, inflammatory caspases and inflammasomes play important roles in several diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, neuronal injuries, such as Alzheimer's disease, Parkinson's disease, stroke, cerebral ischemic cell death, multiple sclerosis and Down syndrome. Some human hereditary or acquired diseases have been linked to elevated IL-1β such as cryopyrin-associated periodic syndroms (CAPS) directly linked to NLRP3 mutations.

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