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AdipoGen Life Sciences
Ferulenol
50
CHF
CHF 50.00
In stock
AG-CN2-0011-M0011 mgCHF 50.00
AG-CN2-0011-M0055 mgCHF 200.00
AG-CN2-0011-M01010 mgCHF 340.00
| Product Details | |
|---|---|
| Synonyms | 4-Hydroxy-3-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)-2H-chromen-2-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C24H30O3 |
| MW | 366.5 |
| CAS | 6805-34-1 |
| Source/Host Chemicals | Isolated from Ferula communis. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in 100% ethanol, methanol or DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | NJJDBBUWWOAOLD-CFBAGHHKSA-N |
| Smiles | OC(C1=CC=CC=C1O2)=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)C2=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Prenylated 4-hydroxycoumarin.
- Anti-tumor compound [2].
- Cytotoxic [2].
- Stimulator of tubulin polymerization in vitro [2].
- Inhibitor of colchicine binding to tubulin [2].
- Antitubercular antibiotic with potent antibacterial activity [3].
- Anti-coagulant, pro-haemorrhagic compound with higher activity than warfarin [4].
- Shows hepatocyte toxicity [1, 4].
- Disrupts mitochondrial membrane potential [5, 6].
- Potent L-malate:quinone oxidoreductase (PfMQO) inhibitor in Plasmodium falciparum.
- Antimalarial.
Product References
- Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L: O. Fraigui, et al.; Vet. Hum. Toxicol. 44, 5 (2002)
- Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol: C. Bocca, et al.; Planta Med. 68, 1135 (2002)
- Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis): G. Appendino, et al.; J. Nat. Prod. 67, 210 (2004)
- Characterization of anti-coagulant properties of prenylated coumarin ferulenol: M. Monti, et al.; Biochim. Biophys. Acta 1770, 1437 (2007)
- Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle: M. Lahouel, et al.; BBRC 355, 252 (2007)
- Disruption of mitochondrial membrane potential by ferulenol and restoration by propolis extract: antiapoptotic role of propolis: B.H. Nadia, et al.; Acta Biol. Hung. 60, 385 (2009)
- Biochemical studies of membrane bound Plasmodium falciparum mitochondrial L-malate:quinone oxidoreductase, a potential drug target: E.D. Hartuti, et al.; BBA Bioenerg. 1859, 191 (2018)
- Plasmodium Parasite Malate-Quinone Oxidoreductase Functionally Complements a Yeast Deletion Mutant of Mitochondrial Malate Dehydrogenase: T. Ito, et al.; Microbiol. Spectr. ahead of print (2023)
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