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AdipoGen Life Sciences

Curcumin (high purity)

CHF 45.00
In stock
AG-CN2-0059-M01010 mgCHF 45.00
AG-CN2-0059-M05050 mgCHF 95.00
AG-CN2-0059-M250250 mgCHF 340.00
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Fax  +41 61 926 6049
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Product Details
Synonyms BRN 2306965; CCRIS 3257; NSC 32982; NSC 687842; CI 75300
Product Type Chemical
Properties
Formula

C21H20O6
MW 368.4
Merck Index 14: 2673
CAS 458-37-7
Source/Host Chemicals Synthetic. Originally isolated from turmeric (Curcuma longa).
Purity Chemicals ≥98% (HPLC)
Appearance Yellow-orange crystalline powder.
Solubility Soluble in methanol, ethanol, ethyl acetate, acetone, methylene chloride, dimethylformamide or methyl ethyl ketone.
Other Product Data

Note: This highly purified product is free of demethoxy- and bis-demethoxycurcumin and does not contain 30-40% bioactive impurities
InChi Key VFLDPWHFBUODDF-FCXRPNKRSA-N
Smiles COC1=CC(\C=C\C(=O)CC(=O)\C=C\C2=CC(OC)=C(O)C=C2)=CC=C1O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of anti-apoptotic gene products), proliferation (HER-2, EGFR and AP-1), survival (PI3K/AKT pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-4), tumorigenesis and development (Shh, Gli), metabolism (PPARγ, Nrf2), epigenetics (HDACs, HATs, DNA methyltransferase I and microRNAs) and inflammation (NLRP3, TLR4, NF-κB, TNF, IL-6, IL-1, COX-2 and 5-LOX).
  • Anti-angiogenic. Anti-metastatic. Anti-invasive. Chemopreventive.
  • Sonic hedgehog (Shh) signaling pathway modulator. Downregulates Shh and Gli1.
  • Anti-inflammatory. Potent inhibitor of NF-κB, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS; NOSII). Downregulates the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12 and chemokines. Inhibits TLR4 and NLRP3 signaling.
  • Modulates several key transcription factors. Down-regulate transcription factors NF-κB, AP-1 and Egr-1. Down-regulates the expression of COX-2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1. Down-regulate growth factor receptors (such as EGFR and HER2) and inhibits the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases.
  • Neuroprotective. Anti-amyloid activity.
  • Cardioprotective. p300/CBP-HAT inhibitor.
  • Regulates lipid metabolism and downregulates obesity. Activates peroxisome proliferator-activated receptor-γ (PPARγ) and Nrf2 cell-signaling pathways.
  • Epigenetic agent. Interacts with histone deacetylases (HDACs), histone acetyltransferases (HATs), DNA methyltransferase I and microRNAs.
  • Proteasome modulator/inhibitor.
Product References
  1. Anticancer potential of curcumin: preclinical and clinical studies: B.B. Aggarwal, et al.; Anticancer Res. 23, 363 (2003) (Review)
  2. Multiple biological activities of curcumin: a short review: R.K. Maheshwari, et al.; Life Sci. 78, 2081 (2006) (Review)
  3. Antioxidant and anti-inflammatory properties of curcumin: V.P. Menon & A.R. Sudheer; Adv. Exp. Med. Biol. 595, 105 (2007) (Review)
  4. Modulation of transcription factors by curcumin: S. Shishodia, et al.; Adv. Exp. Med. Biol. 595, 127 (2007) (Review)
  5. Antitumor, anti-invasion, and antimetastatic effects of curcumin: G. Kuttan, et al.; Adv. Exp. Med. Biol. 595, 173 (2007) (Review)
  6. Neuroprotective effects of curcumin: G.M. Cole, et al.; Adv. Exp. Med. Biol. 595, 197 (2007) (Review)
  7. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases: B.B. Aggarwal & K.B. Harikumar; Int. J. Biochem. Cell Biol. 41, 40 (2009) (Review)
  8. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals: B.B. Aggarwal; Annu. Rev. Nutr. 30, 173 (2010) (Review)
  9. Development of curcumin as an epigenetic agent: S. Fu & R. Kurzrock; Cancer 116, 4670 (2010) (Review)
  10. The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer: F.H. Sarkar, et al.; Cancer Metastasis Rev. 29, 383 (2010) (Review)
  11. Curcumin and obesity: evidence and mechanisms: L. Alappat & A.B. Awad; Nutr. Rev. 68, 729 (2010) (Review)
  12. Curcumin: a potential neuroprotective agent in Parkinson's disease: R.B. Mythri & M.M. Bharath; Curr. Pharm. Des. 18, 91 (2012) (Review)
  13. Targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment: N. Hasima & B.B. Aggarwal; Curr. Med. Chem. 21, 1583 (2014)
  14. Curcumin as a MicroRNA Regulator in Cancer: A Review: A.A. Momtazi, et al.; Rev. Physiol. Biochem. Pharmacol. 171, 1 (2016) (Review)
  15. Curcumin: A Natural Pan-HDAC Inhibitor in Cancer: S.S. Soflaei, et al.; Curr. Pharm. Des. 24, 123 (2018) (Review)
  16. Impact of curcumin on toll-like receptors: M. Boozari, et al.; J. Cell Physiol. 234, 12471 (2019) (Review)
  17. Curcumin: a modulator of inflammatory signaling pathways in the immune system: K.R. Kahkhaie, et al.; Inflammopharmacol. 27, 885 (2019) (Review)
  18. Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies: D.J.Den Hartogh, et al.; Nutrients 12, 118 (2020) (Review)
  19. Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies: D.J.Den Hartogh, et al.; Nutrients 12, 58 (2020) (Review)
  20. The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties: M.A. Panaro, et al.; Int. J. Mol. Sci. 21, 2299 (2020) (Review)
  21. Curcumin as an Antiviral Agent: M.R. Jennings & R.J. Parks; Viruses 12, 1242 (2020) (Review)
  22. COVID-19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin? A.Saeedi-Boroujeni, et al.; Basic. Clin. Pharmacol. Toxicol. 128, 37 (2021) (Review)
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