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AdipoGen Life Sciences
Andrastin A
110
CHF
CHF 110.00
In stock
AG-CN2-0144-C250250 µgCHF 110.00
AG-CN2-0144-M0011 mgCHF 290.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula |
C28H38O7 |
| MW | 486.6 |
| CAS | 174232-42-9 |
| Source/Host Chemicals | Isolated from Aspergillus fumigatus. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | Off-white solid. |
| Solubility | Soluble in DMSO, methanol, ethanol, ethyl acetate or chloroform. Insoluble in water or hexane. |
| InChi Key | SNSSSENJBPCLPM-OXILWVMOSA-N |
| Smiles | [H]C(=O)[C@@]12CC[C@H](OC(C)=O)C(C)(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])C=C(C)[C@@]2(C)C(=O)C(C)=C(O)[C@@]12C(=O)OC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Mycotoxin [1, 5, 7, 8].
- Protein farnesyltransferase (PFTase) inhibitor [1-3].
- Anti-cancer compound [1-3].
- Directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells [4, 6].
Product References
- Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. I. Producing strain, fermentation, isolation, and biological activities: S. Omura, et al.; J. Antibiot. 49, 414 (1996)
- Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. II. Structure and biosynthesis: R. Uchida, et al.; J. Antibiot. 49, 414 (1996)
- Andrastins A-C, New Protein Farnesyltransferase Inhibitors, Produced by Penicillium sp. FO-3929: K. Shiomi, et al.; THL 37, 1265 (1996)
- Enhancement of drug accumulation by andrastin A produced by Penicillium sp. FO-3929 in vincristine-resistant KB cells: M.C. Rho, et al.; J. Antibiot. 51, 68 (1998)
- Andrastins A-D, Penicillium roqueforti Metabolites consistently produced in blue-mold-ripened cheese: K.F. Nielsen, et al.; J. Agric. Food Chem. 53, 2908 (2005)
- Andrastin A and barceloneic acid metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implications: D.P. Overy, et al.; Mycol. Res. 109, 1243 (2005)
- Proteolytic activity, mycotoxins and andrastin A in Penicillium roqueforti strains isolated from Cabrales, Valdeon and Bejes; Tresviso local varieties of blue-veined cheeses: M.A. Fernandez-Bodega, et al.; Int. J. Food Microbiol. 136, 18 (2009)
- In vitro cytotoxicity of fungi spoiling maize silage: R.R. Rasmussen, et al.; Food Chem. Tox. 49, 31 (2011)
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