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AdipoGen Life Sciences
Meleagrin
190
CHF
CHF 190.00
In stock
AG-CN2-0451-M0011 mgCHF 190.00
| Product Details | |
|---|---|
| Synonyms | 6-O-Methyloxaline |
| Product Type | Chemical |
| Properties | |
| Formula |
C23H23N5O4 |
| MW | 433.5 |
| CAS | 71751-77-4 |
| Source/Host Chemicals | Isolated from Penicillium sp. |
| Purity Chemicals | ≥90% (HPLC) |
| Appearance | Yellow adhered film. |
| Solubility | Soluble in DMSO or ethanol. |
| InChi Key | JTJJJLSLKZFEPJ-ZAYCRUKZSA-N |
| Smiles | CON1C2=C(C=CC=C2)[C@@]2(C=C(O)C(=O)N3C(=CC4=CN=CN4)C(=O)N[C@@]123)C(C)(C)C=C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Protect from light. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Mycotoxin.
- Alkaloid antibiotic.
- Bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor.
- Antineoplastic activity.
- Moderate cytotoxicity against A-549 and HL-60 cell lines. Induces cell cycle arrest through G2/M phase, presumably by inhibiting tubulin polymerization.
- Antifouling agent against the barnacle Balanus amphitrite.
Product References
- Studies on fungal products. VII. The structures of meleagrin and 9-O-p-bromobenzoylmeleagrin: K. Kawai, et al.; Chem. Pharm. Bull. 32, 94 (1984)
- Study of the alkaloid composition of the food-infecting penicilles: T.A. Reshetilova, et al.; Food Addit. Contam. 12, 461 (1995)
- Production of mycotoxins on artificially and naturally infested building materials: K.F. Nielsen, et al.; Mycopathologia 145, 43 (1999)
- Alkaloids from a deep ocean sediment-derived fungus Penicillium sp. and their antitumor activities: L. Du, et al.; J. Antibiot. 63, 165 (2010)
- iTRAQ-based proteomic profiling of the barnacle Balanus amphitrite in response to the antifouling compound meleagrin: Z. Han, et al.; J. Proteome Res. 12, 2090 (2013)
- Meleagrin, a new FabI inhibitor from Penicillium chryosogenum with at least one additional mode of action: C.J. Zheng, et al.; PLoS One 8, e78922 (2013)
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