Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
T-2 Toxin
85
CHF
CHF 85.00
In stock
AG-CN2-0473-M0011 mgCHF 85.00
AG-CN2-0473-M0055 mgCHF 340.00
| Product Details | |
|---|---|
| Synonyms | Epoxytrichothecene; Fusariotoxin T-2; Insariotoxin; Mycotoxin T-2; NSC 138780 |
| Product Type | Chemical |
| Properties | |
| Formula |
C24H34O9 |
| MW | 466.5 |
| CAS | 21259-20-1 |
| RTECS | YD0100000 |
| Source/Host Chemicals | Isolated from fungus Fusarium tricinctum. |
| Purity Chemicals | ≥98% (TLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO (30mg/ml), ethanol (20mg/ml) or dichloromethane. |
| InChi Key | BXFOFFBJRFZBQZ-CNLOIQPPSA-N |
| Smiles | [H][C@@]12O[C@]3([H])C=C(C)[C@H](C[C@]3(COC(C)=O)[C@@](C)([C@H](OC(C)=O)[C@H]1O)[C@]21CO1)OC(=O)CC(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Common trichothecene mycotoxin, which can infect grain crops causing alimentary toxic aleukia in humans and animals.
- Inhibits DNA and RNA synthesis in vivo and in vitro and can induce apoptosis. In vivo the compound rapidly metabolizes to HT-2 mycotoxin (a major metabolite).
- Inhibits protein synthesis through its high binding affinity to peptidyl transferase, which is an integral part of the 60S ribosomal subunit, resulting in activation of JNK/p38 MAPKs.
- Interferes with the metabolism of membrane phospholipids and increases liver lipid peroxides.
- Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in brain.
- Reactive oxygen species (ROS) inducer.
Product References
- The structures of toxins from two strains of Fusarium tricinctum: J.R. Bamburg, et al.; Tetrahedron 24, 3329 (1968)
- Measurement of the stability of T-2 toxin in aqueous solution: J. Mary, et al.; Chem. Res. Tox. 6, 524 (1993)
- T-2 toxin-induced apoptosis in lymphoid organs of mice: J. Shinozuka, et al.; Exp. Toxicol. Pathol. 49, 387 (1997)
- Apoptotic cellular damage in mice after T-2 toxin-induced acute toxicosis: T. Ihara, et al.; Nat. Toxins 5, 141 (1997)
- T-2 toxin-induced apoptosis in hematopoietic tissues of mice: J. Shinozuka, et al.; Toxicol. Pathol. 26, 674 (1998)
- Effect of T-2 toxin on blood-brain barrier permeability monoamine oxidase activity and protein synthesis in rats: J. Wang, et al.; Food Chem. Toxicol. 36, 955 (1998)
- Cytotoxicity and related effects of T-2 toxin on cultured Vero cells: C. Bouaziz, et al.; Toxicon 48, 343 (2006)
- Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways: K. Doi & K. Uetsuka; Int. J. Mol. Sci. 12, 5213 (2011)
- T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods: Y. Li, et al.; J. Agric. Food Chem. 59, 3441 (2011)
- The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig: J. Seeboth, et al.; Vet. Res. 43, 1 (2012)
- Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update: Q.H. Wu, et al.; Arch. Toxicol. 88, 1309 (2014)
Related Products
